SR-BI/SCARB1 蛋白, Mouse (HEK293, His-Fc)

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells.Both isoform 1 and isoform 2 act as high-density lipoprotein (HDL) receptors, promoting cholesterol ether uptake and HDL-dependent cholesterol efflux.SR-BI/SCARB1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

SR-BI/SCARB1 作为一种多功能受体，具有与各种配体结合的能力，包括磷脂、胆固醇酯、脂蛋白、磷脂酰丝氨酸和凋亡细胞。同工型 1 和同工型 2 都是高密度脂蛋白 (HDL) 的受体，介导胆固醇醚的选择性摄取并促进 HDL 依赖性胆固醇流出。此外，SR-BI/SCARB1 在细胞表面和含载脂蛋白 B (apoB) 的脂蛋白以及修饰脂蛋白之间运输游离胆固醇和酯化胆固醇方面发挥着作用，尽管效率低于 HDL。该受体还可以通过其磷脂酰丝氨酸结合活性参与凋亡细胞的吞噬作用。值得注意的是，SR-BI/SCARB1 的 C 端区域与 PDZK1 相互作用，突显了其参与复杂细胞过程和信号通路的潜在作用。

Mouse

HEK293

C-hFc;C-His

Q61009 (P33-V440)

20778  [NCBI]

PSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQV

115-120 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.