TRAILR4/TNFRSF10D 蛋白, Human (HEK293, His-Avi)

TRAILR4/TNFRSF10D Protein, a receptor for TRAIL, lacks the ability to induce apoptosis due to a truncated death domain. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4/TNFRSF10D in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi) is 156 a.a., with molecular weight of 38-45 kDa.

TRAILR4/TNFRSF10D 蛋白作为细胞毒性配体 TRAIL 的受体发挥作用，尽管它包含截短的死亡结构域，使其无法诱导细胞凋亡。矛盾的是，TRAILR4/TNFRSF10D 不仅不能诱导细胞凋亡，而且还对 TRAIL 介导的细胞凋亡发挥保护作用。关于其激活 NF-kappa-B 通路的能力存在相互矛盾的信息，一些研究表明它不能诱导该通路，而其他研究则认为它具有激活 NF-kappa-B 的能力。TRAILR4/TNFRSF10D 与 TRAIL 相互作用的双重性质，既作为受体又作为抗凋亡的保护因子，强调了其在细胞对 TRAIL 信号传导反应中调节功能的复杂性。

Human

HEK293

C-Avi;C-His

Q9UBN6 (A56-H211)

8793  [NCBI]

38-45 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.