2. Anti-infection
  3. RSV
  4. RSV-IN-5

RSV-IN-5 (Compound 4) 是一种有效的野生型和突变呼吸道合胞病毒 (RSV) 融合蛋白的双重抑制剂。RSV-IN-5 不仅对野生型 A2 F 蛋白 (EC50=2.0 nM)，而且对 D486N 突变 F 蛋白 (EC50=8.1 nM) 都表现出有效的抗 RSV 活性。

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RSV-IN-5 Chemical Structure

RSV-IN-5 Chemical Structure

CAS No. : 2415018-86-7

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RSV-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RSV-IN-5 (Compound 4) is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. RSV-IN-5 exhibits potent anti-RSV activities against not only wild-type A2 F protein (EC50=2.0 nM), but also D486N-mutant F protein (EC50=8.1 nM)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEp-2 EC50
2 nM
Compound: 12h
Inhibition of Human respiratory syncytial virus A2 Fusion protein expressed in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by XTT assay
Inhibition of Human respiratory syncytial virus A2 Fusion protein expressed in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by XTT assay
[PMID: 32550994]
HEp-2 EC50
8.1 nM
Compound: 12h
Inhibition of Human respiratory syncytial virus Fusion protein D486N mutant expressed in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by XTT assay
Inhibition of Human respiratory syncytial virus Fusion protein D486N mutant expressed in Hep2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by XTT assay
[PMID: 32550994]
分子量

503.64

Formula

C28H37N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RSV-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSV-IN-52415018-86-7RSVRespiratory syncytial virusFusion proteinRSV InhibitorInhibitorinhibitorinhibit

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目录号：
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