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  4. RU265 trichloride

RU265 trichloride 

目录号: HY-47847 纯度: ≥98.0%
COA 产品使用指南

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Ru265 trichloride 是一种细胞渗透性线粒体钙单转运体 (MCU) 抑制剂，可用于缺血性脑卒中的研究。

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RU265 trichloride Chemical Structure

RU265 trichloride Chemical Structure

CAS No. : 27056-01-5

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规格 价格 是否有货
1 mg ￥1125
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RU265 trichloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Ru265 trichloride is a cell-permeable mitochondrial calcium uniporter (MCU) inhibitor and can be used for the research of ischemic stroke[1].

IC50 & Target

Mitochondrial calcium uniporter[1]
体外研究
(In Vitro)

Ru265 (1-10 μM; 30 min or 24 h) produces a concentration-dependent protection of cortical neurons against oxygen–glucose deprivation (OGD)[1].
Ru265 (10 μM; 30 min) blocks calpain activation in cortical neurons subjected to OGD[1].
Ru265 (50 μM; 24 or 48 h) preserves mitochondrial respiration and glycolysis in OGD-treated cortical neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RU265 trichloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Mouse cortical neurons
Concentration: 1-10 μM
Incubation Time: 24 h before OGD (90 min)
Result: Produced a concentration-dependent elevation of cell viability 24 h later with an EC50 of 5.0 µM.
体内研究
(In Vivo)

Ru265 (3-30 mg/kg; i.p.; once) produces dose-dependent increases in seizure-like behaviours in mice[1].
Ru265 (1-10 mg/kg; i.p.; once) reduces hypoxic/ischemic-induced sensorimotor deficits and brain injury in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57/Bl6 mice[1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection, once
Result: Dose-dependently increased pro-convulsant effects.
分子量

529.66

Formula

Cl5H24N9Ru2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (285 KB)

产品使用指南 (1538 KB)
参考文献

RU265 trichloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU265 trichloride27056-01-5Otherscortical neuronoxygen–glucose deprivationOGDmitochondrial calcium uniporterMCUC57/Bl6Inhibitorinhibitorinhibit

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目录号：
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