D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

目录号: HY-100714A 纯度: 99.81%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

D-AP5 (D-APV) 是一种选择性和竞争性 NMDA 受体拮抗剂，K_d 为 1.4 μM。D-AP5 抑制 NMDA 受体的谷氨酸结合位点。

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D-AP5 Chemical Structure

CAS No. : 79055-68-8

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3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in Water	￥1045	In-stock
1 mg	￥304	In-stock
5 mg	￥950	In-stock
10 mg	￥1600	In-stock
50 mg	￥7250	In-stock
100 mg		询价
200 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of D-AP5:

DL-AP5 In-stock
L-AP5 询价
DL-AP5 sodium 询价

MCE 顾客使用本产品发表的 16 篇科研文献

: D-AP5 purchased from MCE. Usage Cited in: CNS Neurosci Ther. 2022 Nov 15. [Abstract]; Treatment with the AMDAR inhibitor (NBQX) and NMDAR inhibitor (D-AP5) effectively reduce the expression of NMDAR (NR1, NR2A/2B) and AMPAR (GluA1, GluA2) in PFC, respectively.

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K_d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors^[1]^[2].

IC₅₀ & Target

NMDA^[1]

体内研究
(In Vivo)

D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented^[2].
D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

197.13

Formula

C₅H₁₂NO₅P

CAS 号

79055-68-8

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O 中的溶解度 : 2 mg/mL (10.15 mM; 超声助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.0728 mL	25.3640 mL	50.7279 mL
5 mM	1.0146 mL	5.0728 mL	10.1456 mL
10 mM	0.5073 mL	2.5364 mL	5.0728 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (507.28 mM); 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.81%

选择批次：

Data Sheet (616 KB) SDS (393 KB)

COA (189 KB) HNMR (249 KB) RP-HPLC (217 KB) MS (80 KB)

产品使用指南 (1538 KB)

参考文献

[1]. R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75. [Content Brief]

[2]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34. [Content Brief]

[3]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17. [Content Brief]

Animal Administration ^[1]	Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75. [Content Brief] [2]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34. [Content Brief] [3]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17. [Content Brief]

Animal Administration
^[1]

Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75. [Content Brief]

[2]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34. [Content Brief]

[3]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17. [Content Brief]

D-AP5 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.0728 mL	25.3640 mL	50.7279 mL	126.8199 mL
	5 mM	1.0146 mL	5.0728 mL	10.1456 mL	25.3640 mL
	10 mM	0.5073 mL	2.5364 mL	5.0728 mL	12.6820 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-AP579055-68-8D-APV D-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

Customer Review

Other Forms of D-AP5:

MCE 顾客使用本产品发表的 16 篇科研文献

D-AP5 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

D-AP5 相关分类

完整储备液配制表

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D-AP5 (Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)

Customer Review

Other Forms of D-AP5:

D-AP5 相关抗体

MCE 顾客使用本产品发表的 16 篇科研文献

D-AP5 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

D-AP5 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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