1. 重组蛋白
  2. Viral Proteins
  3. HPV Proteins

HPV Proteins  (人类乳突病毒蛋白)

Human papillomavirus (HPV) is an infectious human virus of the skin. As most papillomaviruses do, HPV can cause papillomas, or skin lesions. low-risk HPV are much more common than high-risk HPV among humans and often do not cause any symptoms. In fact, only 18 types of HPV pose a cancer risk, mostly for anogenital cancers. Papillomaviruses are small, non-enveloped, icosahedral DNA viruses that have a diameter of 52–55 nm. The viral particles consist of a single double-stranded, circular DNA genome of about 8000 bp that contain approximately eight ORFs. The ORF can be divided into three functional parts: the early (E) region that encodes proteins (E1–E7) necessary for viral replication; the late (L) region that encodes the structural proteins (L1–L2) that are required for virion assembly; and a largely non-coding part that is referred to as the long control region (LCR), which contains cis elements that are necessary for the replication and transcription of viral DNA. The viral E proteins are transcribed from the early promoter (e.g. P97 in HPV 31) whereas the L proteins are transcribed principally from the late promoter (P742 in HPV 31).

目录号 产品名 / 同用名 种属 表达系统
  • HY-P72260
    Protein E6, HPV16 (His)

    蛋白 E6

    E6; Protein E6

    Virus E. coli
    HPV16 E6 是一种病毒磷酸蛋白,具有致癌活性,属人乳头瘤病毒早期蛋白家族。HPV16 E6 通过蛋白酶体降解 pRB 释放 E2F 而激活细胞周期。HPV16 E6 可与 E6 协同永生化细胞并中和 E5 毒性,同时激活 AP-1/NF-κB 通路、下调 E-钙粘蛋白以增强迁移侵袭,是宫颈癌的核心靶点。Protein E6, HPV16 (His) 是重组的 HPV E6 蛋白,由 E. coli 表达,带有 N-6*His 标签。
  • HY-P72259
    Protein E7, HPV16 (His)

    病毒蛋白 E7

    E7; Protein E7

    Virus E. coli
    HPV16 E7 是一种病毒磷酸蛋白,具有致癌活性,属人乳头瘤病毒早期蛋白家族。HPV16 E7 通过蛋白酶体降解 pRB 释放 E2F 而激活细胞周期。HPV16 E7 可与 E6 协同永生化细胞并中和 E5 毒性,同时激活 AP-1/NF-κB 通路、下调 E-钙粘蛋白以增强迁移侵袭,是宫颈癌的核心靶点。Protein E7, HPV (His) 是重组的 HPV E7 蛋白,由 E. coli 表达,带有 N-6*His 标签。
  • HY-P700389
    Protein E7, HPV (N-His, C-His)

    蛋白 E7

    Protein E7

    Virus E. coli
    HPV蛋白E7可以诱导休眠细胞进入细胞周期,促进有效利用细胞DNA复制机制进行病毒基因组复制。通过翻译和反式激活活动,E7 破坏 RB1-E2F1 复合物并激活 E2F1 调节的 S 期基因。Protein E7, HPV (N-His, C-His) 是重组的 HPV 的蛋白 E7,由 E. coli 表达,带有 N-6*His, C-6*His 标签。
目录号 产品名 作用方式 纯度