2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BW-180C

BW-180C  (Synonyms: [D-Ala2, D-Leu5]-Enkephalin; DADLE)

目录号: HY-105343 纯度: 99.92%
COA 产品使用指南

摩尔计算器

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) 是水溶性的多肽类阿片受体 (Opioid Receptor) 激动剂。

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Custom Peptide Synthesis

BW-180C Chemical Structure

BW-180C Chemical Structure

CAS No. : 63631-40-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥772
In-stock
5 mg ￥616
In-stock
10 mg ￥960
In-stock
25 mg ￥1920
In-stock
50 mg ￥3120
In-stock
100 mg ￥4720
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

BW-180C 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.

IC50 & Target

Opioid Receptor[1]
体外研究
(In Vitro)

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BW-180C 相关抗体:

Cell Viability Assay[1]

Cell Line: Human neuroblastoma cells, SH-SY5Y cells
Concentration: 100 pM to 10 μM
Incubation Time: 24-72 hours
Result: Significantly inhibited cellular transcription.

Western Blot Analysis[1]

Cell Line: Primary cortical neurons
Concentration: 100 nM
Incubation Time: 72 hours
Result: Treatment significantly decreased phosphorylation of RNA polymerase II at both Ser 2 and Ser 5.
体内研究
(In Vivo)

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group[2]. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- and delta-opioid receptors[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200 to 250 g[2]
Dosage: 5 mg/kg
Administration: Administered intravenously into the inferior vena cava
Result: After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
Animal Model: Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)[3]
Dosage: 5 mg/kg
Administration: Injected intraperitoneally 15 min prior to I/R
Result: The serum levels of AST and ALT in the serum DADLE group were significantly lower.
分子量

569.65

Formula

C29H39N5O7
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (438.87 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7555 mL 8.7773 mL 17.5546 mL
5 mM 0.3511 mL 1.7555 mL 3.5109 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.92%

COA (284 KB) HNMR (130 KB) LCMS (86 KB) 元素分析报告 (208 KB)

产品使用指南 (1538 KB)
参考文献

BW-180C 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7555 mL 8.7773 mL 17.5546 mL 43.8866 mL
5 mM 0.3511 mL 1.7555 mL 3.5109 mL 8.7773 mL
10 mM 0.1755 mL 0.8777 mL 1.7555 mL 4.3887 mL
15 mM 0.1170 mL 0.5852 mL 1.1703 mL 2.9258 mL
20 mM 0.0878 mL 0.4389 mL 0.8777 mL 2.1943 mL
25 mM 0.0702 mL 0.3511 mL 0.7022 mL 1.7555 mL
30 mM 0.0585 mL 0.2926 mL 0.5852 mL 1.4629 mL
40 mM 0.0439 mL 0.2194 mL 0.4389 mL 1.0972 mL
50 mM 0.0351 mL 0.1755 mL 0.3511 mL 0.8777 mL
60 mM 0.0293 mL 0.1463 mL 0.2926 mL 0.7314 mL
80 mM 0.0219 mL 0.1097 mL 0.2194 mL 0.5486 mL
100 mM 0.0176 mL 0.0878 mL 0.1755 mL 0.4389 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BW-180C63631-40-3[D-Ala2, D-Leu5]-Enkephalin DADLEOpioid ReceptorInhibitorinhibitorinhibit

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目录号：
HY-105343
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