FGFR4-IN-1

目录号: HY-100631 纯度: 99.89%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

FGFR4-IN-1 是有效的 FGFR4 抑制剂，IC₅₀ 值为 0.7 nM。

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FGFR4-IN-1 Chemical Structure

CAS No. : 1708971-72-5

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1194	In-stock
1 mg	￥420	In-stock
5 mg	￥1100	In-stock
10 mg	￥1800	In-stock
25 mg	￥3100	In-stock
50 mg	￥4700	In-stock
100 mg	现货	询价
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

•Heliyon. 2024 May 13.

FGFR4-IN-1 相关产品

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC₅₀ of 0.7 nM.

IC₅₀ & Target

FGFR4

0.7 nM (IC₅₀)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	8.9 nM Compound: 6a	Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human Hep3B cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]
Huh-7	IC₅₀	17.3 nM Compound: 6a	Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]
Huh-7	IC₅₀	25 nM Compound: 69	Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay	[PMID: 32930584]
SK-HEP1	IC₅₀	> 10000 nM Compound: 6a	Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method Antiproliferative activity against human SKHEP1 cells without FGFR4 gene amplification assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method	[PMID: 30987781]

体外研究
(In Vitro)

FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC₅₀ of 7.8 nM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

493.52

Formula

C₂₄H₂₇N₇O₅

CAS 号

1708971-72-5

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 6.4 mg/mL (12.97 mM; 加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0263 mL	10.1313 mL	20.2626 mL
5 mM	0.4053 mL	2.0263 mL	4.0525 mL
10 mM	0.2026 mL	1.0131 mL	2.0263 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.89%

选择批次：

Data Sheet (598 KB) SDS (251 KB)

COA (172 KB) RP-HPLC (261 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1?

Cell Assay ^[1]	Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H₂O. Cells are washed 3 times with H₂O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC₅₀) using XLFit software. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1?

Cell Assay
^[1]

Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H₂O. Cells are washed 3 times with H₂O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC₅₀) using XLFit software.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1?

FGFR4-IN-1 相关分类

Neurological Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0263 mL	10.1313 mL	20.2626 mL	50.6565 mL
	5 mM	0.4053 mL	2.0263 mL	4.0525 mL	10.1313 mL
	10 mM	0.2026 mL	1.0131 mL	2.0263 mL	5.0657 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-11708971-72-5FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FGFR4-IN-1

Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献