2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Nitromifene

Nitromifene  (Synonyms: CI-628)

目录号: HY-100266
产品使用指南

摩尔计算器

Nitromifene 是一个雌激素受体 (ER) 拮抗剂。

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Nitromifene Chemical Structure

Nitromifene Chemical Structure

CAS No. : 10448-84-7

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Nitromifene 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nitromifene is an antagonist of estrogen receptor (ER).

IC50 & Target

ER[1]
体外研究
(In Vitro)

Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nitromifene 相关抗体:
分子量

444.52

Formula

C27H28N2O4
CAS 号
中文名称

硝米芬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay

MCF 7 cells are used in this study. The experiment is carried out in 6-well cluster plates. To each well is added 5 mL of a suspension of 2×105 cells in log phase growth. Medium is changed after 48 h and after 96 h, medium is replaced with 5 mL of serum-free medium containing 2 nM of the radioligand. Nitromifene is dissolved in DMSO (5 μL) to give final concentrations of 0, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM. Nonspecific binding is determined in incubations to which the radioinert counterpart of the radioligand is added at a concentration of 1 μM. Incubations are run in triplicate for 1 h at 37°C.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Nitromifene 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitromifene10448-84-7CI-628硝米芬CI628CI 628Estrogen Receptor/ERRInhibitorinhibitorinhibit

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