Toll-like Receptor (TLR) Inhibitors

TLR3

TLR8

TLR9

TLR2

TLR4

TLR7

TLR1

TLR6

Toll-like Receptor (TLR) Inducers, Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	TLR3	TLR8	TLR9	TLR2	TLR4	TLR7	TLR1	TLR6	Purity
Lipopolysaccharides, from E. coli O55:B5					TLR4
Resatorvid					TLR4				99.95%
Resiquimod		TLR8				TLR7			99.95%
ODN 1826 sodium			TLR9						98.79%
C29				TLR2					≥98.0%
Imiquimod						TLR7			99.96%
Hydroxychloroquine sulfate			TLR9			TLR7			99.99%
Pam3CSK4 TFA				TLR2			TLR1		99.66%
Enpatoran		TLR8, IC₅₀: 24.1 nM (in HEK293 cells) TLR8, IC₅₀: 620 nM (in peripheral blood mononuclear cells (PBMCs)) TLR8, IC₅₀: 120 nM ( in whole blood (WB) cells)				TLR7, IC₅₀: 11.1 nM (in HEK293 cells) TLR7, IC₅₀: 68.3 nM (in peripheral blood mononuclear cells (PBMCs)) TLR7, IC₅₀: 2.2 nM ( in whole blood (WB) cells)			99.77%
ODN 1826			TLR9
CU-CPT 4a	TLR3, IC₅₀: 3.44 μM (in RAW 264.7 cells)								98.91%
Imiquimod hydrochloride						TLR7			99.77%
Agatolimod			TLR9
Diprovocim				TLR2			TLR1		98.35%
Telratolimod		TLR8				TLR7			98.98%
CU-CPT22				TLR2			TLR1		≥99.0%
TLR4-IN-C34					TLR4				99.85%
Motolimod		TLR8							98.12%
ODN 2216			TLR9
ODN 1018			TLR9
AT791			TLR9, IC₅₀: 0.04 μM			TLR7, IC₅₀: 3.33 μM			98.77%
Polyinosinic-polycytidylic acid sodium	TLR3								99.4%
Atractylenolide I			TLR9			TLR7			99.87%
Selgantolimod		TLR8							98.23%
CU-T12-9				TLR2, EC₅₀: 52.9 nM (in HEK-Blue cells)			TLR1, EC₅₀: 52.9 nM (in HEK-Blue cells)		98.94%
MMG-11				TLR2					99.11%
ODN 2395			TLR9						98.39%
Agatolimod sodium			TLR9
Neoseptin 3					TLR4, EC₅₀: 18.5 μM				99.57%
Enpatoran hydrochloride		TLR8, IC₅₀: 24.1 nM				TLR7, IC₅₀: 11.1 nM			99.33%
Schaftoside					TLR4				99.67%
CL097		TLR8				TLR7			99.89%
TLR7/8 agonist 1 dihydrochloride		TLR8				TLR7			99.89%
Isofraxidin					TLR4				99.00%
CL075		TLR8							99.25%
Sparstolonin B				TLR2	TLR4				99.54%
Gardiquimod diTFA		TLR8				TLR7			≥99.0%
ODN 1668			TLR9						≥99.0%
Robinin				TLR2	TLR4				98.77%
FSL-1 TFA				TLR2				TLR6	99.76%
CAY10614					TLR4, IC₅₀: 1.675 μM (in HEK293 cells)				98.04%
TLR9-IN-1			human TLR9, IC₅₀: 7 nM						99.80%
IAXO-102					TLR4				≥98.0%
CU-CPT-9a		TLR8, IC₅₀: 0.5 nM							99.36%
CL264						TLR7			98.63%
Okanin					TLR4				98.64%
CU-CPT17e	TLR3	TLR8	TLR9						99.00%
Monophosphoryl lipid A					TLR4				≥99.0%
Loxoribine						TLR7			99.64%
NecroX-7					TLR4				99.69%
TLR7/8-IN-1		TLR8				TLR7			99.92%
E6446 dihydrochloride			TLR9			TLR7			99.96%
GSK2245035						TLR7			99.85%
TLR7/8 agonist 1		TLR8				TLR7
CpG ODN 10101			TLR9
DSR-6434						TLR7, EC₅₀: 7.2 nM (Human) TLR7, EC₅₀: 4.6 nM (Mice)			99.55%
Gardiquimod		TLR8				TLR7			99.24%
L48H37					TLR4
CU-CPT-8m		TLR8, IC₅₀: 67 nM							99.98%
TLR7/8 agonist 3		TLR8				TLR7			99.96%
LHC-165						TLR7			≥98.0%
ODN 20844			TLR9			TLR7
AZD8848						TLR7			98.08%
Imiquimod maleate						TLR7			99.25%
TLR7/8 agonist 4		TLR8				TLR7			99.04%
Fosfenopril					TLR4				99.89%
ODN M362			TLR9
Toll-like receptor modulator		TLR8				TLR7			99.36%
1V209						TLR7			99.67%
CU-115		TLR8, IC₅₀: 1.04 μM				TLR7, IC₅₀: 50 μM			99.55%
CU-CPT9b		TLR8, IC₅₀: 0.7 nM TLR8, Kd: 21 nM							99.03%
PF-4878691						TLR7			99.89%
L6H21					TLR4				99.46%
MAPK-IN-1					TLR4
TLR7 agonist 6						TLR7, EC₅₀: ~4 nM			98.08%
TLR7 agonist 3						TLR7			98.35%
Polygalasaponin F					TLR4				99.74%
AN-3485	TLR3			TLR2	TLR4
TLR7 agonist 1						TLR7, IC₅₀: 90 nM			98.95%
ODN 2395 sodium			TLR9
Diprovocim-X				TLR2			TLR1		98.64%
TMX-201						TLR7
Resiquimod-d₅		TLR8				TLR7			99.84%
MMG-11 quarterhydrate				TLR2					99.09%
TLR7 agonist 4						TLR7, EC₅₀: 4.3 nM			98.87%
ODN 24987			TLR9
SM-324405						human TLR7, pEC₅₀: 7.3 Rat TLR7, pEC₅₀: 6.6 TLR7, EC₅₀: 50 nM			98.24%
BBIQ						TLR7, EC₅₀: 59.1 nM (Human TLR7)			99.85%
MC-Val-Cit-PAB-Amide-TLR7 agonist 4		TLR8				TLR7			99.39%
CL097 hydrochloride		TLR8				TLR7			99.51%
Resiquimod (GMP)		TLR8				TLR7
TLR7/8 agonist 8		TLR8, EC₅₀: 12 nM				TLR7, EC₅₀: 27 nM
FSL-1				TLR2				TLR6
Pam3CSK4				TLR2			TLR1
TLR4-IN-C34-C2-amide-C6-OH					TLR4
AXC-715 hydrochloride		TLR8				TLR7
ODN 1668 sodium			TLR9						≥99.0%
RKH acetate					TLR4				99.45%
E6446			TLR9			TLR7			≥98.0%
(S)-Hydroxychloroquine			TLR9			TLR7
(R)-Hydroxychloroquine			TLR9			TLR7
Guretolimod						TLR7
TLR7/8 agonist 4 TFA		TLR8				TLR7
TLR8 agonist 2 hydrochloride		TLR8, EC₅₀: 3 nM				TLR7, EC₅₀: 33.33 μM
TLR8 agonist 2		TLR8, EC₅₀: 3 nM				TLR7, EC₅₀: 33.33 μM
UC-1V150						TLR7
TLR7-IN-1						TLR7, IC₅₀: 0.001 μM
WYJ-2				TLR2
SMU-L11						TLR7, EC₅₀: 0.024 μM
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH					TLR4
TLR7 agonist 14						TLR7, IC₅₀: 18 nM
TLR7 agonist 7						TLR7, EC₅₀: ~4 nM
E104						TLR7
3M-011		TLR8				TLR7
ODN M326			TLR9
TLR7 agonist 8						TLR7, EC₅₀: ~4 nM
NF-κB-IN-14					TLR4
TLR7 agonist 9						TLR7
Xanthine oxidase-IN-6					TLR4
Vidutolimod			TLR9
Mumefural					TLR4
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH					TLR4
TLR7 agonist 17						human TLR7, EC₅₀: 12 nM mTLR7, EC₅₀: 17 nM
Kdo2-Lipid A ammonium					TLR4
Polyinosinic-polycytidylic acid potassium	TLR3
Eritoran					TLR4
Pam3CSK4-Biotin				TLR2			TLR1
ssRNA40 sodium		TLR8				TLR7
Hydroxychloroquine sulfate (Standard)			TLR9			TLR7
ODN 24888			TLR9			TLR7
ORN 02 sodium		TLR8
ORN 02		TLR8
TLR7 agonist 5						TLR7, EC₅₀: ~4 nM
ORN 06 sodium						TLR7
BBIQ (GMP)						human TLR7, EC₅₀: 59.1 nM
Chloranil					TLR4

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