2. Anti-infection Protein Tyrosine Kinase/RTK
  3. Parasite Ephrin Receptor
  4. Antimalarial agent 37

Antimalarial agent 37（compound 33）是一种针对 II 型激酶的选择性抑制剂，具有抗疟原虫活性。Antimalarial agent 37 对癌细胞 HepG2 和 MCF7 具有细胞毒性和选择性。

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Antimalarial agent 37 Chemical Structure

Antimalarial agent 37 Chemical Structure

CAS No. : 2982633-16-7

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Antimalarial agent 37 相关抗体

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生物活性

Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].

体外研究
(In Vitro)

Antimalarial agent 37（0-50 nM，72 h）具有抗疟原虫活性，对于菌株 Dd2 和 3D7 的 EC50值是 31 nM 和 35 nM[1]。
Antimalarial agent 37 具有微粒体稳定性，在小鼠肝微粒体中的半衰期是 41.4 min，清除率是 17 μL/min/mg [1]。
Antimalarial agent 37（0-5000 nM，48 h）对于细胞 HepG2 和 MCF7 具有细胞毒性，EC50 值是 2850 和 3540 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 37 相关抗体:

Cell Proliferation Assay[1]

Cell Line: P. falciparum Dd2 and P. falciparum 3D7 strains
Concentration: 0-50 nM
Incubation Time: 72 h
Result: Exhibited antiplasmodial activities with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7.

Cell Viability Assay[1]

Cell Line: HepG2, MCF7
Concentration: 0-5000 nM
Incubation Time: 48 h
Result: Revealed cytotoxicity in HepG2 and MCF7, with EC50 values of 2850 nM and 3540 nM as well as selectivity index of 92 and 114, respectively
分子量

661.66

Formula

C32H29F6N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献

Antimalarial agent 37 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antimalarial agent 372982633-16-7Antimalarial agent37Antimalarial agent-37ParasiteEphrin ReceptorantimalarialP. falciparumHepG2MCF7Inhibitorinhibitorinhibit

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