Auristatin E (Synonyms: 澳瑞他汀 E；奥利斯他汀 E)

目录号: HY-15582 纯度: 99.82%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Auristatin E 是一种细胞毒性微管蛋白聚合抑制剂，具有选择性抗肿瘤活性。Auristatin E 是抗体-药物偶联药物 (ADC) 中的细胞毒素。Auristatin E 通过阻断微管蛋白的聚合抑制细胞分裂，有望用于 B 细胞恶性肿瘤的研究。Auristatin E 是 Dolastatin 10 (HY-15580) 的合成类似物，由四个氨基酸组成的线性肽。

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Auristatin E Chemical Structure

CAS No. : 160800-57-7

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规格	价格	是否有货
5 mg	￥350	In-stock
10 mg	￥490	In-stock
50 mg	￥920	In-stock
100 mg	￥1289	In-stock
250 mg	￥2578	In-stock
500 mg	￥4125	In-stock
1 g		询价
5 g		询价

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Customer Review

Other Forms of Auristatin E:

Auristatin E (GMP) 询价

Auristatin E 相关产品

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

生物活性
纯度 & 产品资料
参考文献

生物活性

Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids^[1]^[2]^[3].

IC₅₀ & Target

Auristatin

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	> 1.37 nM Compound: 2a	Growth inhibition of human BxPC3 cells incubated for 48 hrs by MTT assay Growth inhibition of human BxPC3 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
BXPC-3	GI₅₀	> 1.37 nM Compound: Auristatin E	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28926240]
BXPC-3	GI₅₀	> 1.37 nM Compound: Auristatin E	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28895394]
DU-145	GI₅₀	0.424 nM Compound: 2a	Growth inhibition of human DU145 cells incubated for 48 hrs by MTT assay Growth inhibition of human DU145 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
DU-145	GI₅₀	0.424 nM Compound: Auristatin E	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28926240]
DU-145	GI₅₀	0.424 nM Compound: Auristatin E	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28895394]
KM-20L2	GI₅₀	0.492 nM Compound: 2a	Growth inhibition of human KM20L2 cells incubated for 48 hrs by MTT assay Growth inhibition of human KM20L2 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
KM-20L2	GI₅₀	0.492 nM Compound: Auristatin E	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28926240]
KM-20L2	GI₅₀	0.492 nM Compound: Auristatin E	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28895394]
MCF7	GI₅₀	0.232 nM Compound: 2a	Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT assay Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
MCF7	GI₅₀	0.232 nM Compound: Auristatin E	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28926240]
MCF7	GI₅₀	0.232 nM Compound: Auristatin E	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28895394]
NCI-H460	GI₅₀	0.533 nM Compound: 2a	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
NCI-H460	GI₅₀	0.533 nM Compound: Auristatin E	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28926240]
NCI-H460	GI₅₀	0.533 nM Compound: Auristatin E	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28895394]
SF-268	GI₅₀	0.492 nM Compound: 2a	Growth inhibition of human SF268 cells incubated for 48 hrs by MTT assay Growth inhibition of human SF268 cells incubated for 48 hrs by MTT assay	[PMID: 28211277]
SF-268	GI₅₀	0.492 nM Compound: Auristatin E	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28926240]
SF-268	GI₅₀	0.492 nM Compound: Auristatin E	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28895394]

体外研究
(In Vitro)

Auristatin E (1-10000 nM, 2 小时) 对 L2987 人肺腺癌细胞和多种血液细胞系有细胞毒作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Auristatin E (0.25 mg/kg, 皮下注射，单次剂量，连续 80 天) 能够抑制皮下移植了 L2987 人肺腺癌或 3396 人乳腺癌的裸鼠中的肿瘤生长^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts^[2]
Dosage:	0.25 mg/kg
Administration:	s.c., a single dose for 80 days
Result:	Showed median tumor volume when nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts were injected with conjugates or drug.

分子量

732.01

Formula

C₄₀H₆₉N₅O₇

CAS 号

160800-57-7

性状

固体

颜色

White to light yellow

中文名称

澳瑞他汀 E；奥利斯他汀 E

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (136.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3661 mL	6.8305 mL	13.6610 mL
5 mM	0.2732 mL	1.3661 mL	2.7322 mL
10 mM	0.1366 mL	0.6831 mL	1.3661 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.82%

选择批次：

Data Sheet (614 KB) SDS (393 KB)

COA (293 KB) HNMR (271 KB) RP-HPLC (267 KB) LCMS (92 KB)

产品使用指南 (1538 KB)

参考文献

[1]. MADDON Paul J, et al. PSMA ANTIBODIES AND PROTEIN MULTIMER. 2002 October 23. WO 03/034903 A2

[2]. Peter D. Senter, et al. PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO. 2005 Jan. 13. US 2005/0009751 A l.

[3]. LAW, Che-Leung, et al. TREATMENT OF IMMUNOLOGICAL DISORDERS 5 USING ANTI-CD30 ANTIBODIES. 2002 November 20. WO 03/043583 A2.

Auristatin E 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3661 mL	6.8305 mL	13.6610 mL	34.1525 mL
	5 mM	0.2732 mL	1.3661 mL	2.7322 mL	6.8305 mL
	10 mM	0.1366 mL	0.6831 mL	1.3661 mL	3.4153 mL
	15 mM	0.0911 mL	0.4554 mL	0.9107 mL	2.2768 mL
	20 mM	0.0683 mL	0.3415 mL	0.6831 mL	1.7076 mL
	25 mM	0.0546 mL	0.2732 mL	0.5464 mL	1.3661 mL
	30 mM	0.0455 mL	0.2277 mL	0.4554 mL	1.1384 mL
	40 mM	0.0342 mL	0.1708 mL	0.3415 mL	0.8538 mL
	50 mM	0.0273 mL	0.1366 mL	0.2732 mL	0.6831 mL
	60 mM	0.0228 mL	0.1138 mL	0.2277 mL	0.5692 mL
	80 mM	0.0171 mL	0.0854 mL	0.1708 mL	0.4269 mL
	100 mM	0.0137 mL	0.0683 mL	0.1366 mL	0.3415 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Auristatin E160800-57-7澳瑞他汀 E奥利斯他汀 EMicrotubule/TubulinADC CytotoxinADC Payloadcytotoxicantitumor activityADCapoptosisxenograft mouse modelsB-cell malignanciesInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Auristatin E (Synonyms: 澳瑞他汀 E；奥利斯他汀 E)

Customer Review

Other Forms of Auristatin E: