Cabazitaxel (Synonyms: XRP6258; RPR-116258A; taxoid XRP6258)

目录号: HY-15459 纯度: 99.91%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Cabazitaxel 是天然紫杉烷脱乙酰基巴卡丁III 的半合成衍生物，具有显著的抗肿瘤功效。

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Cabazitaxel Chemical Structure

CAS No. : 183133-96-2

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
1 mg	￥156	In-stock
5 mg	￥312	In-stock
10 mg	￥500	In-stock
50 mg	￥800	In-stock
100 mg	￥1500	In-stock
500 mg	￥4500	In-stock
1 g		询价
5 g		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of Cabazitaxel:

MCE 顾客使用本产品发表的 17 篇科研文献

: Cabazitaxel purchased from MCE. Usage Cited in: Prostate. 2018 Feb;78(3):166-177. [Abstract]; Western blot analysis of apoptosis marker PARP in stable cell lines treated with 50 or 100 nM Cabazitaxel.

: Cabazitaxel purchased from MCE. Usage Cited in: Oncotarget. 2016 May 17;7(20):28891-902. [Abstract]; Western blot analyses for Brachyury and AR expression in prostate cell lines treated with Docetaxel (Doc) or with Cabazitaxel (Cab). Graphs represent the densimetric semi-quantification of western blot images.

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	GI₅₀	1.483 nM Compound: 3	Growth inhibition of human A431 cells by MTT assay Growth inhibition of human A431 cells by MTT assay	[PMID: 24405702]
A549	GI₅₀	1.483 nM Compound: 3	Growth inhibition of human A549 cells by MTT assay Growth inhibition of human A549 cells by MTT assay	[PMID: 24405702]
A549	IC₅₀	15 nM Compound: Cabazitaxel	Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 34058663]
A549/TR	IC₅₀	62.5 nM Compound: Cabazitaxel	Cytotoxicity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Cytotoxicity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 34058663]
BGC-823	GI₅₀	467.2 nM Compound: 3	Growth inhibition of human BGC823 cells by MTT assay Growth inhibition of human BGC823 cells by MTT assay	[PMID: 24405702]
DU-145	GI₅₀	1.429 nM Compound: 3	Growth inhibition of human DU145 cells by MTT assay Growth inhibition of human DU145 cells by MTT assay	[PMID: 24405702]
HeLa	GI₅₀	1.799 nM Compound: 3	Growth inhibition of human HeLa cells by MTT assay Growth inhibition of human HeLa cells by MTT assay	[PMID: 24405702]
HL-60	GI₅₀	4.736 nM Compound: 3	Growth inhibition of human HL60 cells by MTT assay Growth inhibition of human HL60 cells by MTT assay	[PMID: 24405702]
HT-1080	GI₅₀	1.406 nM Compound: 3	Growth inhibition of human HT1080 cells by MTT assay Growth inhibition of human HT1080 cells by MTT assay	[PMID: 24405702]
K562	GI₅₀	4.186 nM Compound: 3	Growth inhibition of human K562 cells by MTT assay Growth inhibition of human K562 cells by MTT assay	[PMID: 24405702]
KB	IC₅₀	20 nM Compound: Cabazitaxel	Cytotoxicity against human KB cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Cytotoxicity against human KB cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 34058663]
MCF7	GI₅₀	1.187 nM Compound: 3	Growth inhibition of human MCF7 cells by MTT assay Growth inhibition of human MCF7 cells by MTT assay	[PMID: 24405702]
MES-SA/Dx5	IC₅₀	15 nM Compound: Cabazitaxel	Growth inhibition of human MES-SA/Dx5 cells after 72 hrs by SRB assay Growth inhibition of human MES-SA/Dx5 cells after 72 hrs by SRB assay	[PMID: 29251920]
NCI-H524	IC₅₀	0.26 nM Compound: Cabazitaxel	Cytotoxicity in human NCI-H524 cells pre-incubated for 2 hrs followed by compound wash out and subsequently incubated for 70 hrs by Cell Titer Glo assay Cytotoxicity in human NCI-H524 cells pre-incubated for 2 hrs followed by compound wash out and subsequently incubated for 70 hrs by Cell Titer Glo assay	[PMID: 30735385]
PANC-1	GI₅₀	1.283 nM Compound: 3	Growth inhibition of human PANC1 cells by MTT assay Growth inhibition of human PANC1 cells by MTT assay	[PMID: 24405702]
SGC-7901	GI₅₀	0.3553 nM Compound: 3	Growth inhibition of human SGC7901 cells by MTT assay Growth inhibition of human SGC7901 cells by MTT assay	[PMID: 24405702]
U-937	GI₅₀	0.5391 nM Compound: 3	Growth inhibition of human U937 cells by MTT assay Growth inhibition of human U937 cells by MTT assay	[PMID: 24405702]

体外研究
(In Vitro)

The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

835.93

Formula

C₄₅H₅₇NO₁₄

CAS 号

183133-96-2

性状

固体

颜色

White to off-white

结构分类

Others

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (119.63 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1963 mL	5.9814 mL	11.9627 mL
5 mM	0.2393 mL	1.1963 mL	2.3925 mL
10 mM	0.1196 mL	0.5981 mL	1.1963 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.99 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.99 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.99 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.96%

选择批次：

Data Sheet (635 KB) SDS (557 KB)

COA (207 KB) HNMR (205 KB) RP-HPLC (194 KB) LCMS (140 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29. [Content Brief]

[2]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095. [Content Brief]

Cell Assay ^[1]	The cytotoxicity of CBX-loaded ANs and free Cabazitaxel (CBX) is evaluated with MTT assay. Cells are seeded onto a 96-well plate at a density of 3000 cells per well and cultured for 24 h. CBX-loaded ANs and free CBX are diluted to predetermined concentrations with PBS and added into each well. Blank AN, AN-ICG and free CBX solvent (a mixture of Tween-80 and anhydrous alcohol) are added as well to different final concentrations. The incubation continued for another 48 hours. 20 µL MTT solutions (5 mg/mL in PBS) are added into each well and cells are incubated for another 4 hours under 37°C. Subsequently the medium is removed and 150 µL dimethyl sulphoxide (DMSO) is added to dissolve the purple formazan salt crystals. Then the absorbance is measured by a microplate reader at 490 nm. The cells treated with medium are evaluated as controls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	To evaluate the antitumor efficiency of the combined chemotherapy and PTT in vivo, mice bearing 4T1 tumor are randomLy divided into 6 treatment groups (n=5). Treatment begin when the tumors reached 50 mm³-100 mm³. The mice are intravenously injected with saline, AN-ICG, free Cabazitaxel (CBX), AN-CBX and AN-ICG-CBX (ICG 2 mg/kg, CBX 10 mg/kg). 8 hours later, the groups injected with AN-ICG and AN-ICG-CBX is irradiated by the 808 nm laser (0.8 W/cm², 5 min). The length and width of every tumor are measured by a caliper every other day. The formula (volume (mm³) =1/2 × length × width²) is used to calculate the tumor volume. The body weights of these mice are recorded every two days using an electronic balance as well. At the end of the antitumor study, the 4T1 tumor bearing mice are sacrificed to collect the tumors and major organs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29. [Content Brief] [2]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095. [Content Brief]

Cabazitaxel 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1963 mL	5.9814 mL	11.9627 mL	29.9068 mL
	5 mM	0.2393 mL	1.1963 mL	2.3925 mL	5.9814 mL
	10 mM	0.1196 mL	0.5981 mL	1.1963 mL	2.9907 mL
	15 mM	0.0798 mL	0.3988 mL	0.7975 mL	1.9938 mL
	20 mM	0.0598 mL	0.2991 mL	0.5981 mL	1.4953 mL
	25 mM	0.0479 mL	0.2393 mL	0.4785 mL	1.1963 mL
	30 mM	0.0399 mL	0.1994 mL	0.3988 mL	0.9969 mL
	40 mM	0.0299 mL	0.1495 mL	0.2991 mL	0.7477 mL
	50 mM	0.0239 mL	0.1196 mL	0.2393 mL	0.5981 mL
	60 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.4984 mL
	80 mM	0.0150 mL	0.0748 mL	0.1495 mL	0.3738 mL
	100 mM	0.0120 mL	0.0598 mL	0.1196 mL	0.2991 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cabazitaxel183133-96-2XRP6258 RPR-116258A taxoid XRP6258XRP 6258XRP-6258taxoid XRP6258taxoid XRP 6258taxoid XRP-6258Microtubule/TubulinAutophagyInhibitorinhibitorinhibit

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Cabazitaxel (Synonyms: XRP6258; RPR-116258A; taxoid XRP6258)

Customer Review

Other Forms of Cabazitaxel:

MCE 顾客使用本产品发表的 17 篇科研文献

Cabazitaxel 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

Cabazitaxel 相关分类

完整储备液配制表

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Cabazitaxel (Synonyms: XRP6258; RPR-116258A; taxoid XRP6258)

Customer Review

Other Forms of Cabazitaxel:

Cabazitaxel 相关抗体

MCE 顾客使用本产品发表的 17 篇科研文献

Cabazitaxel 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Cabazitaxel 相关抗体:

摩尔计算器

稀释计算器

Cabazitaxel 相关分类

完整储备液配制表

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