2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Fotemustine

Fotemustine  (Synonyms: 福莫司汀; S10036)

目录号: HY-B0733
产品使用指南

摩尔计算器

Fotemustine 是一种 DNA 烷化剂 (DNA alkylator)，具有抗肿瘤作用。

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Fotemustine Chemical Structure

Fotemustine Chemical Structure

CAS No. : 92118-27-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥1350
1 - 2 周
10 mg ￥2200
1 - 2 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Fotemustine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fotemustine is a DNA-alkylating agent, with antitumor activity.

IC50 & Target

DNA Alkylator[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
173 μM
Compound: Fotemustine
Cytotoxicity against human A375 cells after 96 hrs by MTT assay
Cytotoxicity against human A375 cells after 96 hrs by MTT assay
[PMID: 19278757]
A-375 IC50
173 μM
Compound: fotemustine
Cytotoxicity against human A375 cells after 96 hrs by MTT assay
Cytotoxicity against human A375 cells after 96 hrs by MTT assay
[PMID: 18513976]
体外研究
(In Vitro)

Fotemustine is a DNA-alkylating agent. Fotemustine (800 μM) decreases GSH and intracellular GSSG levels but increases the extracellular GSSG-levels rapidly in isolated rat hepatocytes[1]. Fotemustine shows inhibitory effect on several tumor cell lines, with IC50s ranging form 0.05 to 0.18 mM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fotemustine 相关抗体:
分子量

315.69

Formula

C9H19ClN3O5P
CAS 号
性状

固体

颜色

White to yellow

中文名称

福莫司汀
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 3.2 mg/mL (10.14 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1677 mL 15.8383 mL 31.6766 mL
5 mM 0.6335 mL 3.1677 mL 6.3353 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[2]

Cell proliferation assays are performed using MTT. Briefly, cell suspensions containing 2 × 104 viable cells/mL are plated into 96-well dishes and allowed to attach for 48 h at 371C in a 5% CO2 atmosphere. The culture medium is then removed and the cells are incubated for two doubling times at 37°C in the culture medium containing fotemustine (10-3 to 10 mM). When tested, amifostine or WR-1065 (10-4 to 10 mM) is added before Fotemustine for 15 min. Control cultures are exposed to saline for 15 min and then allowed to grow for the same duration in complete culture medium[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Fotemustine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1677 mL 15.8383 mL 31.6766 mL 79.1916 mL
5 mM 0.6335 mL 3.1677 mL 6.3353 mL 15.8383 mL
10 mM 0.3168 mL 1.5838 mL 3.1677 mL 7.9192 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fotemustine92118-27-9S10036福莫司汀S 10036S-10036DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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目录号：
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