1. Protein Tyrosine Kinase/RTK Epigenetics Cell Cycle/DNA Damage Apoptosis
  2. FLT3 HDAC Apoptosis
  3. HDAC-IN-63

HDAC-IN-63 (Compound 63) 是一种双重 FLT3/HDAC 抑制剂 (IC50: 对 FLT3HDAC1 分别为 0.844 和 30.0 nM)。HDAC-IN-63 抑制 MV4-11 细胞增殖 (IC50: 92 nM。HDAC-IN-63在 MV4-11 细胞中诱导细胞凋亡 (apoptosis) 并阻滞细胞周期。HDAC-IN-63 可用于急性髓系白血病 (AML) 的研究。

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HDAC-IN-63 Chemical Structure

HDAC-IN-63 Chemical Structure

CAS No. : 2920046-95-1

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  • 生物活性

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生物活性

HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML)[1].

IC50 & Target

0.844 and 30.0 nM for FLT3 and HDAC1[1]

分子量

529.42

Formula

C25H26Cl2N6O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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产品名称:
HDAC-IN-63
目录号:
HY-149474
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