2. Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK
  4. NLRP3-IN-32

NLRP3-IN-32 (compound 7a) 是一种 3, 4-dihydronaphthalene-1(2H)-one 衍生物，一种 NLRP3 炎症小泡抑制剂。NLRP3-IN-32 可以通过下调 NLPR3 和含有 CARD 的凋亡相关斑点样蛋白 (ASC) 的表达，抑制活性氧 (ROS) 和其他炎症介质的产生来阻断 NLRP3 炎症小体的组装和激活。NLRP3-IN-32 抑制 IκBα 和 NF-κB/p65 的磷酸化以及 p65 的核转位，从而抑制 NF-κB 信号转导。

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NLRP3-IN-32 Chemical Structure

NLRP3-IN-32 Chemical Structure

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NLRP3-IN-32 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 IKK 亚型特异性产品:

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling[1].

IC50 & Target[1]

NLRP3 inflammasome

 

p65

 

体外研究
(In Vitro)

NLRP3-IN-32 (compound 7a; 1.5, 3, 6 μM) 以剂量依赖性方式逆转 LPS (HY-D1056) 刺激 RAW246.7 巨噬细胞炎症因子 TNF-α、IL-6、IL-18 和 IL-1β 的释放[1]。
NLRP3-IN-32 (1.5, 3, 6 μM) 以剂量依赖性清除细胞内 LPS 刺激的 ROS 和 NO 产生，抑制 NLRP3 炎症小泡的激活[1]。
NLRP3-IN-32 (1.5, 3, 6 μM) 对 RAW246.7 细胞具有低毒性，不同浓度下凋亡率分别为 3.8%、5.6% 和 6.8%[1]。
NLRP3-IN-32 (1.5, 3, 6 μM; 24 小时) 剂量依赖性抑制 LPS (1.0 μg/mL; 2 小时) 刺激的 IκBα 磷酸化和 p65 磷酸化，从而抑制 NF-κB 信号通路激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NLRP3-IN-32 相关抗体:
分子量

412.32

Formula

C21H22BrN3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NLRP3-IN-32 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-32NOD-like Receptor (NLR)Reactive Oxygen SpeciesNF-κBIKKNuclear factor-κBNuclear factor-kappaBIκB kinaseI kappa B kinase34-dihydronaphthalene-1(2H)-oneinflammatory vesicleCARDASCIκBαp65Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161329
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