Aptamers
(核酸适配体)
Aptamers are short single-stranded DNA or RNA that can bind to variety of targets, such as proteins, peptides, carbohydrates, and other molecules, by virtue of their tertiary structure, rather than their sequence. The aptamers have a high affinity to target protein similar to antibodies. Compared to antibodies, however, aptamers are small in size and have additional advantages, including improved transport into the cells and lower cost.
Cat. No. |
Product Name |
CAS No. |
Purity |
Chemical Structure |
-
- HY-147080
-
Avacincaptad pegol sodium
|
1491144-00-3 |
98.53% |
Avacincaptad pegol (ARC1905) 是一种靶向补体因子5 (C5) 的核酸适配体,抑制C5剪切为C5a和C5b。Avacincaptad pegol被用于研究与年龄相关的黄斑变性(AMD)。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA ((2′-deoxy-2′-fluoro)C-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-Gm-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-Gm-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[6-[[(2,3-dihydroxypropoxy)carbonyl]amino]hexyl hydrogen phosphate], sodium salt (2:1:39)
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA ((2′-deoxy-2′-fluoro)C-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-Gm-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-Gm-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[6-[[(2,3-dihydroxypropoxy)carbonyl]amino]hexyl hydrogen phosphate], sodium salt (2:1:39)
-
- HY-147081
-
AS 1411
|
301636-59-9 |
|
AS1411是一种靶向核仁素的核酸适配体。AS1411 可以将纳米颗粒、寡核苷酸和小分子输送到癌细胞中,具有抗肿瘤的作用。
|
-
DNA, d(G-G-T-G-G-T-G-G-T-G-G-T-T-G-T-G-G-T-G-G-T-G-G-T-G-G)
DNA, d(G-G-T-G-G-T-G-G-T-G-G-T-T-G-T-G-G-T-G-G-T-G-G-T-G-G)
-
- HY-153999
-
BT200
|
|
98.20% |
BT200 是偶联聚乙二醇的核酸适配体 BT100,可抑制 von Willebrand Factor(VWF) 与血小板糖蛋白GPIb的结合,预防动脉血栓形成。
|
-
PEG40K‐NH‐mGmCmCmAmGmGmGmAmCmCmUmAmAmGmAmCmAmCmAmUmGmUmCmCmCmUmGmGmC‐idT
PEG40K‐NH‐mGmCmCmAmGmGmGmAmCmCmUmAmAmGmAmCmAmCmAmUmGmUmCmCmCmUmGmGmC‐idT
-
- HY-109561
-
Pegaptanib sodium
|
222716-86-1 |
98.09% |
Pegaptanib sodium 是一种靶向血管内皮生长因子 (VEGF)-165 的 RNA适配体。 Pegaptanib 可用于新生血管型老年性黄斑变性的研究。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA ((2′-deoxy-2′-fluoro)C-Gm-Gm-A-A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-(2′-deoxy-2′-fluoro)U-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[5-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]pentyl hydrogen phosphate] (2:1), sodium salt
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA ((2′-deoxy-2′-fluoro)C-Gm-Gm-A-A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-(2′-deoxy-2′-fluoro)U-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[5-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]pentyl hydrogen phosphate] (2:1), sodium salt
-
- HY-153098
-
ARC186
|
|
|
ARC 186 是一种核酸适配体,是高效的补体抑制剂,通过阻断转化酶催化的C5 激活发挥作用。
|
-
fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T
fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T
-
- HY-148100A
-
Emapticap pegol sodium
|
|
|
Emapticap pegol sodium 是促炎趋化因子 C-C 基序配体 2 (CCL2) 的抑制剂。Emapticap pegol sodium 是一种 40 个核苷酸的寡核苷酸适体,在人 (NOX-E36) 和小鼠 (mNOX-E36) 中具有不同的 Spiegelmers (L-RNA 适配子) 形式。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-A-C-G-U-C-C-C-U-C-A-C-C-G-G-U-G-C-A-A-G-U-G-A-A-G-C-C-G-U-G-G-C-U-C-U-G-C-G) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1), sodium salt
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-A-C-G-U-C-C-C-U-C-A-C-C-G-G-U-G-C-A-A-G-U-G-A-A-G-C-C-G-U-G-G-C-U-C-U-G-C-G) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1), sodium salt
-
- HY-148695B
-
ADR58 sodium
|
|
|
ADR58 sodium 是一种高效的选择性人类制瘤素 M (OSM)拮抗剂,可以阻止 OSM 与 gp130 受体的结合,并特异性拮抗 OSM 介导的信号传导。ADR58 sodium 可用于类风湿性关节炎相关疾病研究。
|
-
5'-GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC-3', sodium salt
5'-GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC-3', sodium salt
-
- HY-153836A
-
Anivamersen sodium
|
959716-31-5 |
|
Anivamersen sodium 是一种 RNA 核酸适配体,可逆转凝血因子 factor Ixa 抑制剂 pegnivacogin 的抗凝作用。Pegnivacogin(一种凝血因子IXa的RNA适体抑制剂)和 Anivamersen (一种互补序列反转寡核苷酸)构成了一种新型抗凝系统REG1。
|
-
RNA, (Cm-Gm-Cm-Gm-Gm-Um-Am-Um-Am-Gm-Um-Cm-Cm-Am-Cm), sodium salt
RNA, (Cm-Gm-Cm-Gm-Gm-Um-Am-Um-Am-Gm-Um-Cm-Cm-Am-Cm), sodium salt
-
- HY-153785
-
NH2-C6-ARC186 sodium
|
|
|
NH2-C6-ARC186 sodium 是一种可以偶联到其他肽或分子的、带 NH2-C6 接头的 ARC186 (HY-153098)。ARC186 是一种适体和高效补体抑制剂,通过阻断转化酶催化的 C5 活化起作用。
|
-
NH2-C6-fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T, sodium salt
NH2-C6-fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T, sodium salt
-
- HY-148457
-
Avacincaptad pegol
|
1613641-69-2 |
|
Avacincaptad pegol 是一种核酸适配体,可用作 C5 补体抑制剂,减少炎症相关的视网膜色素上皮 (RPE) 损伤。Avacincaptad pegol caqn 可用于研究 stargardt 黄斑营养不良 (STGD1) 和地理萎缩 (GA)。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA ((2′-deoxy-2′-fluoro)C-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-Gm-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-Gm-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[6-[[(2,3-dihydroxypropoxy)carbonyl]amino]hexyl hydrogen phosphate] (2:1)
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA ((2′-deoxy-2′-fluoro)C-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-Gm-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-Gm-(2′-deoxy-2′-fluoro)C-G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[6-[[(2,3-dihydroxypropoxy)carbonyl]amino]hexyl hydrogen phosphate] (2:1)
-
- HY-153480
-
ARC19499
|
1350667-54-7 |
|
ARC19499 是一种核酸适配体, 与组织因子通路抑制剂(TFPI)特异性结合,阻断 TFPI 对 factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A和B血浆中的凝血酶生成,并恢复凝血。
|
-
RNA, (Gm-Gm-Am-Am-Um-Am-Um-Am-dC-Um-Um-Gm-Gm-dC-Um-dC-Gm-Um-Um-Am-Gm-Gm-Um-Gm-dC-Gm-Um-Am-Um-Am-Um-Am-(3′→3′)-dT), 5′-(6-aminohexyl hydrogen phosphate)
RNA, (Gm-Gm-Am-Am-Um-Am-Um-Am-dC-Um-Um-Gm-Gm-dC-Um-dC-Gm-Um-Um-Am-Gm-Gm-Um-Gm-dC-Gm-Um-Am-Um-Am-Um-Am-(3′→3′)-dT), 5′-(6-aminohexyl hydrogen phosphate)
-
- HY-147079
-
Egaptivon pegol
|
934868-74-3 |
|
Egaptivon pegol (ARC1779) 是一种核酸适配体,阻碍 von Willebrand Factor(VWF)与血小板 GPIb 受体结合。Egaptivon pegol具有抗血栓作用。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA (Gm-Cm-Gm-Um-dG-dC-dA-Gm-Um-Gm-Cm-Cm-Um-Um-Cm-Gm-Gm-Cm-dC-Gm-sp-dT-Gm-dC-dG-dG-dT-Gm-Cm-dC-Um-dC-dC-Gm-Um-dC-Am-Cm-Gm-Cm-(3′→3′)-dT) 5′-[6-(carboxyamino)hexyl hydrogen phosphate]
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA (Gm-Cm-Gm-Um-dG-dC-dA-Gm-Um-Gm-Cm-Cm-Um-Um-Cm-Gm-Gm-Cm-dC-Gm-sp-dT-Gm-dC-dG-dG-dT-Gm-Cm-dC-Um-dC-dC-Gm-Um-dC-Am-Cm-Gm-Cm-(3′→3′)-dT) 5′-[6-(carboxyamino)hexyl hydrogen phosphate]
-
- HY-148100
-
Emapticap pegol
|
1390630-22-4 |
|
Emapticap pegol 是促炎趋化因子 C-C 基序配体 2 (CCL2) 的抑制剂。Emapticap pegol 是一种 40 个核苷酸的寡核苷酸适体,在人 (NOX-E36) 和小鼠 (mNOX-E36) 中具有不同的 Spiegelmers (L-RNA 适配子) 形式。
|
-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-A-C-G-U-C-C-C-U-C-A-C-C-G-G-U-G-C-A-A-G-U-G-A-A-G-C-C-G-U-G-G-C-U-C-U-G-C-G) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1)
Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ether with RNA β-L-(G-C-A-C-G-U-C-C-C-U-C-A-C-C-G-G-U-G-C-A-A-G-U-G-A-A-G-C-C-G-U-G-G-C-U-C-U-G-C-G) 5′-[6-[[2-[(2-hydroxyacetyl)(2-hydroxyethyl)amino]acetyl]amino]hexyl hydrogen phosphate] (2:1)
-
- HY-153834
-
GTI 2040
|
236391-66-5 |
|
GTI-2040 是一种硫代寡核苷酸,靶向人核糖核苷酸还原酶 R2 (ribonucleotide reductase R2) mRNA。GTI-2040 在体外通过下调 核糖核苷酸还原酶 R2 表达抑制癌细胞增殖,并在小鼠人类癌症异种移植模型中显著抑制肿瘤生长。
|
-
DNA, d(P-thio)(G-G-C-T-A-A-A-T-C-G-C-T-C-C-A-C-C-A-A-G)
DNA, d(P-thio)(G-G-C-T-A-A-A-T-C-G-C-T-C-C-A-C-C-A-A-G)
-
- HY-153845
-
RNA Aptamer Broccoli sodium
|
|
|
RNA Aptamer Broccoli (sodium) 是一种49个核苷酸组成的核酸适配体,比 Spinach 和 Spinach2 短得多,在与DFHBI或DFHBI- 1T(绿色荧光蛋白荧光团的可溶性类似物)结合时显示出明亮的绿色荧光。RNA Aptamer Broccoli (sodium) 可用于活细胞中的RNA表达或定位。RNA Aptamer Broccoli (sodium) 在体外表现出与 Spinach2 相似的高折叠效率,但对镁的依赖性明显降低,热稳定性提高。此外,与 Spinach2 不同,Broccoli不需要使用tRNA支架来促进其在体内的折叠。
|
-
5'-GAGACGGUCGGGUCCAGAUAUUCGUAUCUGUCGAGUAGAGUGUGGGCUC-3', sodium salt
5'-GAGACGGUCGGGUCCAGAUAUUCGUAUCUGUCGAGUAGAGUGUGGGCUC-3', sodium salt
-
- HY-153843
-
RNA Aptamer Corn sodium
|
|
|
RNA Aptamer Corn (sodium) 是一种28个核苷酸组成的的核酸适配体,比 Spinach 和 Spinach2 短得多,在与DFHO(红色荧光蛋白固有荧光团的可溶性类似物)结合后显示出明亮的红色荧光。RNA Aptamer Corn (sodium) 可用于可视化活细胞中的RNA表达或定位。Corn-DFHO 在照射时不会产生明显的细胞毒性。最重要的是,与其他核酸适配体-发光基团复合物相比,Corn-DFHO 在体外和体内都表现出显著提高的光稳定性。(36 nt Corn construct: 5'-GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC-3' 由最短的28-nt Corn序列组成,且延伸出4个碱基对的构成茎。)
|
-
5'-CGAGGAAGGAGGUCUGAGGAGGUCACUG-3', sodium salt
5'-CGAGGAAGGAGGUCUGAGGAGGUCACUG-3', sodium salt
-
- HY-153848
-
RNA Aptamer Mango Ⅳ sodium
|
|
|
RNA Aptamer Mango Ⅳ (sodium) 是一种核酸适配体,对TO1-biotin(一种噻唑橙衍生物荧光团)具有极高的亲和力,可用于可视化活细胞中RNA的表达或定位。与最初的 RNA Aptamer Mango Ⅰ相比,RNA Aptamer Mango Ⅳ (sodium) 具有显着改善的荧光特性,结合亲和力和盐依赖性。
|
-
5'-GGCACGUAC-CGA-GG-GAGU-GG- UGA -GG-AUGA- -GG-CGA-----GUACGUGC-3', sodium salt
5'-GGCACGUAC-CGA-GG-GAGU-GG- UGA -GG-AUGA- -GG-CGA-----GUACGUGC-3', sodium salt
-
- HY-153846
-
RNA Aptamer Mango I sodium
|
|
|
RNA Aptamer Mango Ⅰ (sodium) 是由39个核苷酸组成的核酸适配体,对TO1-biotin(一种噻唑橙衍生物荧光团)具有极高的亲和力。RNA Aptamer MangoⅠ (sodium)可用于可视化活细胞中的RNA表达或定位。
|
-
5'-GGCACGUACGAAGGGACGGUGCGGAGAGGAGAGUACGUGC-3', sodium salt
5'-GGCACGUACGAAGGGACGGUGCGGAGAGGAGAGUACGUGC-3', sodium salt
-
- HY-153847
-
RNA Aptamer Mango ΙΙ sodium
|
|
|
RNA Aptamer Mango Ⅱ (sodium) 是一种核酸适配体,对TO1-biotin(一种噻唑橙衍生物荧光团)具有极高的亲和力,可用于可视化活细胞中RNA的表达或定位。与最初的 RNA Aptamer Mango Ⅰ相比,RNA Aptamer Mango Ⅱ 具有显着改善的荧光特性,结合亲和力和盐依赖性。
|
-
5'-GGCACGUACGAAGGAGAGGAGAGGAAGAGGAGAGUACGUGC-3', sodium salt
5'-GGCACGUACGAAGGAGAGGAGAGGAAGAGGAGAGUACGUGC-3', sodium salt
-
- HY-153851
-
RNA Aptamer Peach Ⅱ sodium
|
|
|
RNA Aptamer Peach Ⅱ (sodium) 是一种核酸适配体,对TO3-Biotin(TO3-B,红色通道,ex: 637 nm, em: 658 nm)具有非常高的亲和力,可用于可视化RNA在活细胞中的表达或定位。
|
-
5'-GGCGUAAGGUUAAAAGGUGUGGACGAUGGUGGGAGACCUUACGCC-3', sodium salt
5'-GGCGUAAGGUUAAAAGGUGUGGACGAUGGUGGGAGACCUUACGCC-3', sodium salt