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铁死亡检测

铁死亡检测是一种用于评估细胞因铁胁迫而发生死亡的实验方法。在高浓度铁离子的存在下,细胞内可产生过多的自由基,导致氧化应激和细胞损伤。检测方法包括荧光探针标记、细胞形态学观察、DNA片段化等。铁死亡检测有助于研究细胞铁代谢紊乱与疾病的关系,如贫血、神经系统疾病等。这项研究对于揭示铁在生物体内的作用机制以及潜在的治疗靶点具有重要意义。


Ferroptosis assay is an experimental method used to assess cell death due to iron stress. In the presence of high concentrations of iron ions, excessive free radicals can be generated within cells, leading to oxidative stress and cell damage. Detection methods include fluorescent probe labeling, cell morphology observation, DNA fragmentation, etc. Ferroptosis detection is helpful in studying the relationship between cellular iron metabolism disorders and diseases, such as anemia, neurological diseases, etc. This research is of great significance for revealing the mechanism of iron action in organisms and potential therapeutic targets.