QL47 

QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC₅₀ of 7 nM^[1][2][3].

QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, most likely by targeting an early step in translation elongation^[2].
QL47 inhibits autophosphorylation of BTK on Tyr223 in cells with an EC₅₀ of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC₅₀ of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

447.49

C₂₇H₂₁N₅O₂

1469988-75-7

固体

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

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• [1]. Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8(3):344-349. Published 2017 Feb 3.  [Content Brief]

  [2]. de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295(6):1694-1703.  [Content Brief]

  [3]. Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9(5):1086-1091.  [Content Brief]