FGF-18 蛋白, Human (HEK293, His)

FGF-18 Protein intricately regulates cell proliferation, differentiation, and migration, crucial in normal ossification and bone development for skeletal maturation. It stimulates hepatic and intestinal proliferation, showcasing versatile functions. Interactions with FGFR3 and FGFR4 underscore FGF-18 Protein's significance in modulating intricate signaling pathways for fundamental tissue development and homeostasis. FGF-18 Protein, Human (HEK293, His) is the recombinant human-derived FGF-18 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGF-18 Protein, Human (HEK293, His) is 180 a.a., with molecular weight of ~32 kDa.

FGF-18 蛋白在复杂的细胞增殖、分化和迁移调节中发挥着关键作用。它的不可或缺性延伸到正常骨化和骨骼发育的协调，强调它在骨骼成熟中的关键参与。此外，FGF-18 蛋白具有刺激肝脏和肠道增殖的能力，突出了其在不同组织中的多功能功能。这些细胞过程的介导是通过与 FGFR3 和 FGFR4 的相互作用来促进的，强调了 FGF-18 蛋白在调节复杂信号通路中的重要性，这些信号通路有助于组织发育和体内平衡的基本过程。

Measured by its binding ability in a functional ELISA. Immobilized FGF18 Protein, Human (HEK293, His) at 10 μg/mL (100 μl/well) can bind rat FGFR4 and the EC₅₀ is 1.17 μg/mL.

Human

HEK293

C-6*His

O76093 (E28-A207)

8817  [NCBI]

MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA

Approximately 32 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.