2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Cannabinoid Receptor Bacterial
  4. Rimonabant

Rimonabant  (Synonyms: 利莫那班; SR141716)

目录号: HY-14136 纯度: 99.41%
COA 产品使用指南

摩尔计算器

Rimonabant (SR141716) 是中心大麻素受体 1 (CB1) 高效的、选择性的、能透过血脑屏障的拮抗剂， Ki 值为 1.8 nM。Rimonabant (SR141716) 也能够抑制分枝杆菌膜蛋白3 (MMPL3)。

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Rimonabant Chemical Structure

Rimonabant Chemical Structure

CAS No. : 168273-06-1

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规格 价格 是否有货 数量
5 mg ￥312
In-stock
10 mg ￥500
In-stock
25 mg ￥1000
In-stock
50 mg ￥1600
In-stock
100 mg ￥2400
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Rimonabant:

Rimonabant 相关抗体

Top Publications Citing Use of Products

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

IC50 & Target[1]

CB1

1.8 nM (Ki)

体外研究
(In Vitro)

Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2].
Rimonabant itself (10-12-10-3 M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50 of 4.7±0.2 (IC50 = 20 μM) and a maximal inhibition of 48±2%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rimonabant 相关抗体:
体内研究
(In Vivo)

Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant [1].
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

463.79

Formula

C22H21Cl3N4O
CAS 号
性状

固体

颜色

White to off-white

中文名称

利莫那班
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (269.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1561 mL 10.7807 mL 21.5615 mL
5 mM 0.4312 mL 2.1561 mL 4.3123 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Rimonabant 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1561 mL 10.7807 mL 21.5615 mL 53.9037 mL
5 mM 0.4312 mL 2.1561 mL 4.3123 mL 10.7807 mL
10 mM 0.2156 mL 1.0781 mL 2.1561 mL 5.3904 mL
15 mM 0.1437 mL 0.7187 mL 1.4374 mL 3.5936 mL
20 mM 0.1078 mL 0.5390 mL 1.0781 mL 2.6952 mL
25 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1561 mL
30 mM 0.0719 mL 0.3594 mL 0.7187 mL 1.7968 mL
40 mM 0.0539 mL 0.2695 mL 0.5390 mL 1.3476 mL
50 mM 0.0431 mL 0.2156 mL 0.4312 mL 1.0781 mL
60 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.8984 mL
80 mM 0.0270 mL 0.1348 mL 0.2695 mL 0.6738 mL
100 mM 0.0216 mL 0.1078 mL 0.2156 mL 0.5390 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimonabant168273-06-1SR141716利莫那班SR 141716SR-141716Cannabinoid ReceptorBacterialInhibitorinhibitorinhibit

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