2. GPCR/G Protein
  3. CaSR
  4. Strontium Ranelate

Strontium Ranelate  (Synonyms: 雷尼酸锶; Distrontium renelate; S12911)

目录号: HY-17397 纯度: 99.99%
COA 产品使用指南

摩尔计算器

Strontium Ranelate (S12911) 是一种抗骨质疏松活性分子，其作用是通过减少骨吸收并促进骨形成，从而诱导正骨平衡。Strontium Ranelate 还可以激活非骨骼细胞中的钙敏感受体 (CaSR)，从而导致肌醇 1、4、5-三磷酸生成和丝裂原活化的蛋白激酶信号转导。

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Strontium Ranelate Chemical Structure

Strontium Ranelate Chemical Structure

CAS No. : 135459-87-9

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规格 价格 是否有货 数量
100 mg ￥1000
In-stock
500 mg ￥3500
In-stock
1 g ￥5200
In-stock
5 g   询价  
10 g   询价  

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Other Forms of Strontium Ranelate:

Strontium Ranelate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling[1][2].

体外研究
(In Vitro)

Strontium Ranelate (0.1-1 mM; 22 days; Mouse calvaria cells) treatment shows the expression of mRNA for early osteoblast markers (alkaline phosphatase, ALP) is visualized by day 5, while late markers (osteocalcin, OCN) are detectable only by day 15 and beyond[1].
Strontium Ranelate (0.1-1 mM; 22 days; Mouse calvaria cells) treatment results in significantly increases the mRNA expression of the osteoblastic markers ALP, BSP and OCN at day 22 of MC cell culture[1].
Strontium Ranelate is found to increase alkaline phosphatase activity and prostaglandin E2 production in a COX-2 dependent manner in murine marrow stromal cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Strontium Ranelate 相关抗体:

RT-PCR[1]

Cell Line: Mouse calvaria (MC) cells
Concentration: 0.1 mM, 0.3 mM or 1 mM
Incubation Time: 22 days
Result: The expression of mRNA for early osteoblast markers (ALP) was visualized by day 5, while late markers (OCN) were detectable only by day 15 and beyond.

Western Blot Analysis[1]

Cell Line: Mouse calvaria (MC) cells
Concentration: 0.1 mM, 0.3 mM or 1 mM
Incubation Time: 22 days
Result: Significantly increased the mRNA expression of the osteoblastic markers ALP, BSP and OCN at day 22 of MC cell culture.
体内研究
(In Vivo)

Strontium Ranelate increases bone formation and decreased bone resorption, which results in increased bone mass in the vertebrae of intact adult mice[2].
In intact adult rats, Strontium Ranelate also increases bone mass, as measured by dual-energy X-ray absorptiometry, in lumbar vertebra and femur, and this is confirmed by histological assessment of trabecular bone volume in the tibial metaphysis[2].
Strontium Ranelate is found to decrease bone resorption and to increase bone formation in alveolar bone in normal adult monkeys (Macaca fascicularis), which exhibits extensive bone remodeling[2].
In ovariectomized rats, short-term (3 months) treatment with Strontium Ranelate prevents trabecular bone loss induced by oestrogen deficiency, as demonstrated by bone ash, bone mineral content and histomorphometric analysis in the tibial metaphysis. This effect results from decreased bone resorption while bone formation was maintained. These beneficial effects of Strontium Ranelate on bone mass and microarchitecture in ovariectomized rats are confirmed in long-term experiments. In this long-term study (2 years), the increase in bone mass and microarchitecture induced by Strontium Ranelate results in a marked improvement in bone strength, supporting the beneficial effect of this drug on bone resistance[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

513.49

Formula

C12H6N2O8SSr2
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

雷尼酸锶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

0.1 M HCL 中的溶解度 : 17.5 mg/mL (34.08 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈3))

H2O 中的溶解度 : 2 mg/mL (3.89 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9475 mL 9.7373 mL 19.4746 mL
5 mM 0.3895 mL 1.9475 mL 3.8949 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： Saline

    Solubility: 2 mg/mL (3.89 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Strontium Ranelate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M HCL 1 mM 1.9475 mL 9.7373 mL 19.4746 mL 48.6864 mL
0.1 M HCL 5 mM 0.3895 mL 1.9475 mL 3.8949 mL 9.7373 mL
10 mM 0.1947 mL 0.9737 mL 1.9475 mL 4.8686 mL
15 mM 0.1298 mL 0.6492 mL 1.2983 mL 3.2458 mL
20 mM 0.0974 mL 0.4869 mL 0.9737 mL 2.4343 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9475 mL
30 mM 0.0649 mL 0.3246 mL 0.6492 mL 1.6229 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Strontium Ranelate135459-87-9Distrontium renelate S12911雷尼酸锶S12911S 12911S-12911CaSRCalcium-sensing receptorInhibitorinhibitorinhibit

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