2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Tusamitamab ravtansine

Tusamitamab ravtansine  (Synonyms: SAR-408701; HuMAb2-3-SPDB-DM4)

目录号: HY-P99542 纯度: 99.42%
COA

摩尔计算器

Tusamitamab ravtansine (SAR408701) 是一种针对表达 CEACAM5 的肿瘤细胞的靶向 ADC，由人源化抗 CEACAM5 单克隆抗体组成，通过可裂解接头与强效细胞毒性剂美登木素生物碱 DM4 (HY-12454) 共价连接。Tusamitamab ravtansine 的平均药物抗体比 (DAR) 为 3.8。

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Tusamitamab ravtansine Chemical Structure

Tusamitamab ravtansine Chemical Structure

CAS No. : 2254086-60-5

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规格 价格 是否有货 数量
1 mg ￥7800
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Tusamitamab ravtansine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8[1][2][3].

体外研究
(In Vitro)

Tusamitamab ravtansine (SAR-408701) 的抗体成分与 CEACAM5 的胞外结构域结合，启动 ADC 内化到肿瘤细胞中，随后在细胞质内释放 DM4。DM4 通过破坏微管组装、诱导细胞周期停滞和启动细胞凋亡来引发细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tusamitamab ravtansine 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.42%

COA (172 KB) RP-HPLC (154 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tusamitamab ravtansine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tusamitamab ravtansine2254086-60-5SAR-408701 HuMAb2-3-SPDB-DM4SAR408701SAR 408701Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug ConjugatesCEACAM5tumor cellsmaytansinoidDM4Inhibitorinhibitorinhibit

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