RLN1 - relaxin 1 Gene

中文名称：松弛素 1

种属: Homo sapiens

同用名: H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2

关于 RLN1

功能概要

松弛素是已知的内分泌和自分泌/旁分泌激素，属于胰岛素基因超家族。在人类中存在三种非等位基因松弛素基因，RLN1、RLN2 和 RLN3，其中 RLN1 和 RLN2 具有高度序列同源性。该基因编码的蛋白质合成为单链多肽，但活性形式由通过二硫键连接的 A 链和 B 链组成。松弛素由卵巢产生，以哺乳动物生殖系统为目标，使子宫颈成熟，延长耻骨联合并抑制子宫收缩。它可能在增强精子活力、调节血压、控制心率以及释放催产素和加压素方面具有额外的作用。[RefSeq 提供，2013 年 1 月]

Relaxins are known endocrine and autocrine/paracrine Hormones, belonging to the Insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]