HuR (人抗原 R)

Human Antigen R (HuR), also known as ELAV-like protein 1 (ELAVL1), is an RNA-binding protein that plays a crucial role in the process of RNA metabolism within cells. HuR enhances the stability of mRNA and guides the mRNA to be transported from the nucleus to the cytoplasm through the nuclear pore complex, ensuring that the mRNA reaches the ribosomes for translation. HuR can also interact with translation initiation factors to promote the binding of ribosomes to mRNA, thereby regulating the translation efficiency of mRNA and affecting protein synthesis. By regulating the stability, transportation, and translation of the mRNAs of related genes, HuR plays an important role in tumors, neurodegenerative diseases, and inflammatory diseases^[1][2].