Acetyl-CoA synthetase (乙酰辅酶 A 合酶)

Acetyl-Coenzyme A synthetase (Acs) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). As a crucial enzyme in the Wood-Ljungdahl pathway of carbon fixation, acetyl-CoA synthetase has bifunctional roles, using a nickel-containing bimetallic site to combine carbon monoxide with a methyl group, ultimately converting it into acetyl-CoA. Acetyl-CoA is essential in metabolism and energy generation. The activity of ACS is tightly regulated by complex systems, including carbon flux-mediated gene expression and post-translational regulation via the NAD+/sirtuin-dependent pathway.
Acetyl-CoA synthetase can induce Autophagy, and its mediated histone acetylation plays a significant role in maintaining cellular homeostasis and tumor development^[1][2][3].