1. Signaling Pathways
  2. Claudin

Claudin (Claudin 蛋白)

Claudins 是一个跨膜蛋白家族,是紧密连接(zonulae occludentes)的最重要组成部分。它们有四个跨膜结构域,N 端和 C 端位于细胞质中。Claudins 的表达和功能在多个水平上受多种机制调控。Claudins 从膜上移位似乎在转化细胞中很常见。Ras 或 Ras 介导的信号通路的组成性激活是肿瘤发生过程中的初始步骤之一,与肿瘤转化有因果关系。重要的是,Claudins 在上皮细胞中以组织特异性方式表达,癌症中 Claudins 家族成员之间的变化遵循组织特异性,有时是对比模式。因此,claudin 家族蛋白可能为上皮来源的肿瘤异质性提供潜在线索,除了作为有用的标记物之外,还可能有助于提供适合特定癌症类型的治疗机会。

Claudins are a family of transmembrane proteins, are the most important components of the tight junctions (zonulae occludentes). They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudin expression and functions are regulated at multiple levels and by diverse mechanisms. Delocalization of claudins from membrane appears to be common among the transformed cells. Constitutive activation of Ras or Ras-mediated signaling pathway/s is one of the initial steps during tumorigenesis that is causatively associated with neoplastic transformation. Importantly, claudins are expressed in the epithelial cells and in a tissue-specific manner and changes among claudin family members in cancer follow tissue-specific and sometimes contrasting pattern. Thus, claudin family of proteins may hold the potential cue to the heterogeneity among the tumors of epithelial origin and beyond being useful markers may also help provide therapeutic opportunities suited for specific cancer type[1].

Claudin 相关产品 (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W014507
    9,10-Phenanthrenequinone

    菲醌

    Inhibitor
    9,10-Phenanthrenequinone 是 claudin-5/CLDN5 的抑制剂,通过 NO 合酶/ROS 依赖机制引发细胞凋亡。9,10-Phenanthrenequinone 还促进 Caspase 激活和 DNA 断裂,并降低 CLDN5 表达和蛋白酶体蛋白水解来促进内皮细胞屏障功能障碍。
    9,10-Phenanthrenequinone
  • HY-171152
    NSC 357754 Inhibitor
    NSC 357754 是一种 Claudin 的抑制剂。NSC 357754 能够增加细胞跨上皮电阻和降低特定阳离子通透性。NSC 357754 可用于 Claudin-2 和或 Claudin-15 介导的肠道疾病的研究。
    NSC 357754