1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Amino Acid Oxidase

Amino Acid Oxidase (氨基酸氧化酶)

Amino Acid Oxidase

Amino acid oxidases, including L-amino acid oxidase (LAAO, EC 1.4.3.2) and D-amino acid oxidase (DAAO, EC 1.4.3.3), are classified as FAD-dependent flavoproteins. They utilize flavin adenine dinucleotide (FAD) as a cofactor to catalyze the oxidative deamination of L- or D-amino acids, producing α-keto acids, ammonia, and hydrogen peroxide.
LAAO is widely found in bacteria, fungi, and mammals, and is primarily involved in antibacterial defense, cytotoxicity, and ecological adaptation. For example, LAAO in snake venom induces apoptosis and inhibits platelet aggregation by generating high local concentrations of hydrogen peroxide, thus enhancing its toxic effects. Microbial LAAOs from species such as Pseudoalteromonas and Aspergillus exhibit potent antibacterial activity and can effectively inhibit the growth of Staphylococcus aureus. In human breast milk, LAAO plays a natural antimicrobial role, helping to prevent mastitis.
In contrast, DAAO is mainly distributed in the liver, kidney, and brain of vertebrates, where it degrades D-amino acids to maintain amino acid homeostasis and regulate neural signaling. In particular, DAAO controls the level of D-serine, a co-agonist of NMDA receptors in the brain. Abnormal DAAO activity has been closely associated with neurodegenerative diseases such as schizophrenia and Alzheimer’s disease. Moreover, the hydrogen peroxide produced by DAAO possesses potential antitumor properties and has been explored for tumor-targeted therapies. DAAO also finds broad applications in the biosynthesis of chiral drugs and in D-amino acid detection[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2986
    D-Amino acid oxidase (Immobilized)

    D-氨基酸氧化酶(固定化)

    D-氨基酸氧化酶 (D-Amino acid oxidase) 是一种在动物体内代谢外源 D-氨基酸进行解毒作用的酶。D-氨基酸氧化酶也能调节大脑中 D-丝氨酸的水平。
    D-Amino acid oxidase (Immobilized)
  • HY-117292
    DAO-IN-2 Inhibitor 99.83%
    DAO-IN-2 是一种 d-氨基酸氧化酶 (DAO) 抑制剂 (h-DAO IC50 = 245 nM)。DAO-IN-2 在体内外对 DAAO 具有中等强度的抑制剂作用。DAO-IN-2 可用于 DAAO 相关的精神疾病研究。
    DAO-IN-2
  • HY-P2987
    L-Amino acid oxidase

    L-氨基酸氧化酶

    L-氨基酸氧化酶 (L-Amino acid oxidase) 是一种含有黄素腺嘌呤二核苷酸的同二聚蛋白。L-氨基酸氧化酶可以催化 L-氨基酸立体定向氧化脱氨生成 α-酮酸和氨。
    L-Amino acid oxidase
  • HY-117292R
    DAO-IN-2 (Standard) Inhibitor
    DAO-IN-2 (Standard) 是 DAO-IN-2 (HY-117292) 的分析标准品。本产品用于研究及分析应用。DAO-IN-2 是一种新型 D-氨基酸氧化酶 (DAO) 抑制剂。 DAO-IN-2 在体外和离体体内均表现出中等的 DAO 效力。
    DAO-IN-2 (Standard)

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