1. Gene
  2. GPC1 - glypican 1 Gene

GPC1 - glypican 1 Gene

中文名称:磷脂球蛋白聚糖 1

种属: Homo sapiens

同用名: glypican

基因 ID: 2817 | 基因类型: protein coding

关于 GPC1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,435,663-240,468,076 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 5 paralogues. Broad expression in skin (RPKM 51.0), testis (RPKM 21.8) and 19 other tissues.

功能概要

细胞表面硫酸乙酰肝素蛋白聚糖由膜相关蛋白核心组成,该核心被可变数量的硫酸乙酰肝素链取代。磷脂酰肌醇蛋白聚糖相关的完整膜蛋白多糖家族 (GRIPS) 的成员包含一个通过糖基磷脂酰肌醇键固定在细胞质膜上的核心蛋白。这些蛋白质可能在控制细胞分裂和生长调节中发挥作用。[RefSeq 提供,2008 年 7 月]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

GPC1 基因产物(1)

mRNA Protein Name
NM_002081.3 NP_002072.2 glypican-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables copper ion binding IDA
IDA: 通过直接分析推断
12732622 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30282023 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heparan sulfate proteoglycan catabolic process IDA
IDA: 通过直接分析推断
12732622 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with membrane raft IDA
IDA: 通过直接分析推断
12732622 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPC1 蛋白结构

Glypican

Glypican: Glypican (9 - 552)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 558 a.a.
蛋白主名 其他名称

glypican-1

epididymis secretory sperm binding protein

重组 GPC1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70343 Glypican-1/GPC1 Protein, Human (HEK293, His) P35052-1 (D24-T529) ≥95%

关联疾病

疾病名称 别名
Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1

Simpson-Golabi-Behmel Syndrome

SGBS1

Golabi-Rosen Syndrome

Simpson Dysmorphia Syndrome

Sgbs

Bulldog Syndrome

Dgsx

Sdys

Dysplasia Gigantism Syndrome, X-Linked

X-Linked Dysplasia Gigantism Syndrome

Dgsx Golabi-Rosen Syndrome

Sara Angers Syndrome

Sgb Syndrome

Mental Retardation-Overgrowth Syndrome

Simpson Dysplasia Syndrome

Simpson Syndrome

Simpson-Golabi-Behmel Syndrome 1

Dysplasia Gigantism Syndrome X-Linked

Biliary Atresia

Congenital Biliary Atresia

Isolated Biliary Atresia

Isolated Atresia Of Bile Ducts

Non-Syndromic Biliary Atresia

Atresia Of Bile Duct

Biliary Atresia, Congenital

Atresia Of Bile Ducts

Bile Duct Atresia

Congenital Bile Duct Atresia

Ba - [Biliary Atresia]

Impervious Bile Duct

Atresia Of Common Duct

Biliary Duct Atresia

Bile Ductal Atresia

Cystic Duct Atresia

Keipert Syndrome

Nasodigitoacoustic Syndrome

KPTS

Nasodigitoacoustic Syndrome, Formerly

Hereditary Multiple Exostoses

Multiple Congenital Exostosis

Hereditary Multiple Exostoses 1

Hereditary Multiple Exostoses 2

Hereditary Multiple Exostoses 3

Multiple Exostosis Syndromes

Multiple Ostechondromas

Osteochondromatosis Syndrome

Exostoses Multiple Hereditary

Exostoses, Multiple Hereditary

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Chronic Congestive Splenomegaly
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GPC1 VGNC VGNC:49902
Rattus norvegicus GPC1 RGD RGD:61853
Mus musculus GPC1 MGD MGI:1194891
Felis catus GPC1 VGNC VGNC:67402
Bos taurus GPC1 VGNC VGNC:29523
Macaca mulatta GPC1 VGNC VGNC:104533
Others GPC1 NCBI