CDC37 - cell division cycle 37, HSP90 cochaperone Gene

中文名称：细胞分裂周期 37，HSP90 辅伴侣

种属: Homo sapiens

同用名: P50CDC37

关于 CDC37

功能概要

该基因编码的蛋白质与酿酒酵母细胞分裂周期控制蛋白 CDC 37 高度相似。该蛋白是一种分子伴侣，在细胞信号转导中具有特定功能。它已被证明与 HSP90 和多种蛋白激酶 (包括 CDK4、CDK6、SRC、RAF-1、MOK 以及 eIF2 α 激酶) 形成复合物。它被认为在将 HSP90 导向其目标激酶方面起着关键作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is highly similar to CDC 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with HSP90 and a variety of protein kinases including CDK4, CDK6, Src, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases. [provided by RefSeq, Jul 2008]