2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP RIP kinase Apoptosis Necroptosis
  4. Kongensin A

Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。

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Kongensin A Chemical Structure

Kongensin A Chemical Structure

CAS No. : 885315-96-8

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1 mg ￥9500
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Kongensin A 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 RIP kinase 亚型特异性产品:

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RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications[1].

IC50 & Target

HSP90[1]
RIP3[1]
Apoptosis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
0.12 μM
Compound: 8
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
[PMID: 34236840]
MDA-MB-231 IC50
0.177 μM
Compound: 8
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
[PMID: 34236840]
MDA-MB-468 IC50
0.228 μM
Compound: 8
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT method
[PMID: 34236840]
体外研究
(In Vitro)

Kongensin A (0-15 μM；6 小时；HT29 细胞) 处理以剂量依赖性方式在多种癌细胞系中诱导 caspase 激活和细胞凋亡[1]。
Kongensin A (0 -15 μM；24 hours；HT29细胞) 处理诱导 RIPK1 和致癌激酶如 ERBB2、AKT、EGFR 和 B-raf 的降解，并诱导 HSP90A 和 HSP90B 的上调[1]。
Kongensin A 共价结合 HSP90 中间结构域的半胱氨酸 420，并将 HSP90 与其辅伴侣 CDC37 解离。RIP3 激活需要 HSP90-CDC37 复合物，KA 阻断 LPS/Smac 模拟物/Z-VAD 和 RIP3 聚合诱导的细胞死亡，其中细胞死亡依赖于 RIP3 而不是其上游激酶 RIP1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kongensin A 相关抗体:

Apoptosis Analysis[1]

Cell Line: HT29 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time: 6 hours
Result: Induced caspase activation and apoptosis in a dosage-dependent manner.

Western Blot Analysis[1]

Cell Line: HT29 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time: 24 hours
Result: Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.
分子量

374.47

Formula

C22H30O5
CAS 号
性状

固体

颜色

White to light yellow

初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

COA (279 KB) HNMR (194 KB)

产品使用指南 (1538 KB)
参考文献

Kongensin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kongensin A885315-96-8HSPRIP kinaseApoptosisNecroptosisHeat shock proteinsReceptor-interacting protein kinasesRIPKHSP90necroptosisanti-necroptosisanti-inflammationRIP3CDC37Cys420HSP90AHSP90BInhibitorinhibitorinhibit

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