MDM4 - MDM4 regulator of p53 Gene

中文名称：p53 的 MDM4 调节器

种属: Homo sapiens

同用名: HDMX; MDMX; MRP1; BMFS6

基因 ID: 4194 | 基因类型: protein coding

关于 MDM4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,516,406-204,558,120 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 75 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.7), skin (RPKM 6.5) and 24 other tissues.

功能概要

该基因编码的核蛋白在 N 端包含一个 p53 结合结构域，在 C 端包含一个环指结构域，并显示出与 p53 结合蛋白 MDM2 的结构相似性。这两种蛋白质都与 p53 肿瘤抑制蛋白结合并抑制其活性，并已被证明在多种人类癌症中过度表达。然而，与降解 p53 的 MDM2 不同，该蛋白通过结合其转录激活域来抑制 p53。该蛋白还通过 RING 指结构域与 MDM2 蛋白相互作用，并抑制后者的降解。因此，这种蛋白质可以逆转 p53 的 MDM2 靶向降解，同时保持对 p53 反式激活和凋亡功能的抑制。已经注意到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

MDM4 基因产物(7)

mRNA	Protein	Name
NM_001204171.2	NP_001191100.1	protein Mdm4 isoform 2
NM_001204172.2	NP_001191101.1	protein Mdm4 isoform 3
NM_001278516.2	NP_001265445.1	protein Mdm4 isoform 4
NM_001278517.2	NP_001265446.1	protein Mdm4 isoform 5
NM_001278518.2	NP_001265447.1	protein Mdm4 isoform 6
NM_001278519.2	NP_001265448.1	protein Mdm4 isoform 7
NM_002393.5	NP_002384.2	protein Mdm4 isoform 1

MDM4 蛋白结构

SWIB

zf-RanBP

zf-C3HC4_3

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

protein Mdm4

MDM4, p53 regulator

重组 MDM4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74756	MDM4/MDMX Protein, Human (His)	O15151-1/NP_002384.2 (M1-D134)	≥95%

关联疾病

疾病名称

别名

Bone Marrow Failure Syndrome 6

BMFS6

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Bilateral Retinoblastoma

Unilateral Retinoblastoma

Leukocoria

Leucocoria

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148409	MMRi62		99.58%	否
HY-10412	CEP-1347		98.50%	否
HY-123544	RDR03871	MDM2 Inhibitor	/	否
HY-146806	YL93	Inhibitor	/	否
HY-151169	MDM2/4-p53-IN-1	p53 Inhibitor	/	否
HY-151170	MDM2/4-p53-IN-2		/	否
HY-151171	MDM2/4-p53-IN-3	Inhibitor	/	否
HY-158830	MDM4-targeting ASO sodium		/	否
HY-RS08267	MDM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MDM4	MGD	MGI:107934
Canis familiaris	MDM4	VGNC	VGNC:43107
Felis catus	MDM4	VGNC	VGNC:68224
Macaca mulatta	MDM4	VGNC	VGNC:74693
Rattus norvegicus	MDM4	RGD	RGD:1309306
Bos taurus	MDM4	VGNC	VGNC:31337
Others	MDM4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MDM4 - MDM4 regulator of p53 Gene

关于 MDM4

功能概要

MDM4 基因产物(7)

MDM4 蛋白结构

重组 MDM4 蛋白

关联疾病

直系同源

热门区域

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MDM4 - MDM4 regulator of p53 Gene

关于 MDM4

功能概要

MDM4 基因产物(7)

MDM4 蛋白结构

重组 MDM4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z