2. Apoptosis
  3. MDM-2/p53
  4. YL93

YL93 是 MDM2/4 的双重抑制剂 (Ki=0.64 μM, MDM4; 1.1 nM, MDM2)。YL93 诱导细胞周期停滞和细胞凋亡 (apoptosis)。YL93 显示出 p53 依赖性的细胞生长抑制活性。

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YL93 Chemical Structure

YL93 Chemical Structure

CAS No. : 2771313-42-7

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YL93 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
50.7 nM
Compound: 31
Cytotoxicity against human HCT-116 cells expressing wild type p53 and MDM2 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human HCT-116 cells expressing wild type p53 and MDM2 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
HEK293 IC50
6.25 μM
Compound: 31
Cytotoxicity against HEK293 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against HEK293 cells assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
HeLa IC50
7.37 μM
Compound: 31
Cytotoxicity against human HeLa cells harbouring unstable p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human HeLa cells harbouring unstable p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
MCF7 IC50
0.52 μM
Compound: 31
Cytotoxicity against human MCF7 cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human MCF7 cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
NCI-H460 IC50
0.46 μM
Compound: 31
Cytotoxicity against human NCI-H460 cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human NCI-H460 cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
RKO IC50
0.2 μM
Compound: 31
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
SW480 IC50
2.82 μM
Compound: 31
Cytotoxicity against human SW480 cells harbouring mutant p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human SW480 cells harbouring mutant p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
U2OS IC50
0.37 μM
Compound: 31
Cytotoxicity against human U2OS cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
Cytotoxicity against human U2OS cells expressing wild type p53 assessed as cell growth inhibition incubated for 4 days by CCK-8 assay
[PMID: 35420431]
体外研究
(In Vitro)

YL93 (0.078-2.5 μM; 24 h) 增加 p53、p21、MDM2 的蛋白质水平[1]。
YL93 (0.02-2.5 μM; 24 h) 使细胞周期停滞在 G1[1]。
YL93 (6.25-25 μM; 48 h) 增加凋亡 RKO 细胞[1]。
YL93 (2.5 μM；48 小时) 增加 MDM4 过表达细胞系 H460、MCF-7 和 U-2 OS 中 p53 靶向基因 MDM2、p21 和 PUMA 的转录[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YL93 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.078125 μM, 0.15625 μM, 0.3125 μM, 0.625 μM, 1.25 μM, and 2.5 μM
Incubation Time: 24 hours
Result: Significantly increased the protein level of p53, p21, MDM2.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.02 μM, 0.1 μM, 0.5 μM, 2.5 μM
Incubation Time: 24 hours
Result: Arrested cell cycle at G1 phase.
分子量

711.62

Formula

C37H38Cl2F2N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YL93 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL932771313-42-7YL 93YL-93MDM-2/p53MDM2/4MDM2p21PUMAHCT-116Inhibitorinhibitorinhibit

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