2. Gene
  3. PFN2 - profilin 2 Gene

PFN2 - profilin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白 2

种属: Homo sapiens

同用名: PFL; D3S1319E

基因 ID: 5217 | 基因类型: protein coding

关于 PFN2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,964,904-149,970,895 (from NCBI)

This gene has 18 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in brain (RPKM 148.4), thyroid (RPKM 50.8) and 19 other tissues.

功能概要

该基因编码的蛋白质是一种普遍存在的肌动蛋白单体结合蛋白，属于 profilin 家族。它被认为可以响应细胞外信号调节肌动蛋白聚合。有两种可变剪接的转录变体编码针对该基因描述的不同亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

PFN2 基因产物(2)

mRNA Protein Name
NM_002628.5 NP_002619.1 profilin-2 isoform b
NM_053024.4 NP_444252.1 profilin-2 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
7758455 GOA
enables actin monomer binding IPI
IPI: 通过物理相互作用推断
7758455 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
7758455 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9822597 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
7758455 GOA
involved in negative regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
23153535 GOA
involved in negative regulation of ruffle assembly IMP
IMP: 通过突变表型推断
23153535 GOA
involved in positive regulation of ATP-dependent activity IDA
IDA: 通过直接分析推断
7758455 GOA
involved in positive regulation of actin filament bundle assembly IMP
IMP: 通过突变表型推断
23153535 GOA
involved in positive regulation of actin filament polymerization IGI
IGI: 通过遗传相互作用推断
23153535 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
23153535 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
23153535 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
18573880 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PFN2 蛋白结构

Profilin

Profilin: Profilin (3 - 135)

  • 0
  • 100
  • 140 a.a.
蛋白主名 其他名称

profilin-2

profilin II

重组 PFN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71237 Profilin-2 Protein, Human P35080-1 (M1-F140) ≥95%
HY-P73698 Profilin-2 Protein, Human (His) AAH18049.1 (M1-F140) ≥95%

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10369 PFN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PFN2 VGNC VGNC:102803
Canis familiaris PFN2 VGNC VGNC:49940
Rattus norvegicus PFN2 RGD RGD:621826
Bos taurus PFN2 VGNC VGNC:32776
Mus musculus PFN2 MGD MGI:97550
Others PFN2 NCBI
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