2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. HZ1

Anticancer agent 241 (HZ1) 是一种具有口服活性的首创的细胞周期依赖性激酶样 3 (CDKL3) 特异性抑制剂。Anticancer agent 241 表现出强大的肿瘤抑制作用，并有可能克服 CDK4/6 抑制剂的耐药性。

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HZ1 Chemical Structure

HZ1 Chemical Structure

CAS No. : 3030492-40-8

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HZ1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor[1].

体外研究
(In Vitro)

Anticancer agent 241 (HZ1；2-10 小时；100 nM) 显着降低 pRb 和 CDK4 的水平，从而有效触发细胞周期停滞和肿瘤死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HZ1 相关抗体:

Western Blot Analysis[1]

Cell Line: DLD-1 cells
Concentration: 100 nM
Incubation Time: 2 h, 4 h, 6 h, 8 h, 10 h
Result: Reduced the levels of pRb and CDK4.
体内研究
(In Vivo)

Anticancer agent 241 (HZ1；1 mg/kg；口服管饲；每天 12-14 天) 在小鼠结肠癌模型中具有抗癌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old female athymic nude mice injected with DLD-1 cells[1]
Dosage: 1 mg/kg
Administration: Oral gavage; daily for 12-14 days
Result: Suppressed tumor volume in a mouse model of colon cancer.
分子量

362.43

Formula

C20H22N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HZ1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HZ13030492-40-8HZ 1HZ-1Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesCDKL3 InhibitorAnticancer agentcell cycleorally activeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161847
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