2. Stem Cell/Wnt
  3. Smo
  4. BODIPY-Cyclopamine

BODIPY-Cyclopamine 是一种 Smoothened (SMO) 受体的荧光标记配体。SMO 的活化受到 Patch 蛋白的调控，而过度活化的 SMO 信号通路与肿瘤发生相关。研究中使用纳米荧光素生物发光共振能量转移（NanoBRET）技术，能够敏感地检测 SMO 与 BODIPY-Cyclopamine 之间的共振能量转移，可适用于高通量筛选和动力学分析。研究BODIPY-Cyclopamine 在 SMO 上的结合位点还能够进一步发掘 SMO靶向药物。

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BODIPY-Cyclopamine Chemical Structure

BODIPY-Cyclopamine Chemical Structure

CAS No. : 334658-24-1

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BODIPY-Cyclopamine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BODIPY-Cyclopamine is a fluorescently labeled ligand for the Smoothened (SMO) receptor. The activation of SMO is regulated by Patch protein, and over-activated SMO signaling pathways are associated with tumorigenesis. The NanoBRET (Nanofluorescein bioluminescence resonance energy transfer) technique used in the study can sensitively detect the resonance energy transfer between SMO and BODIPY-Cyclopamine, which can be used for high-throughput screening and kinetic analysis. Studying the binding site of BODIPY-Cyclopamine on SMO can also further explore SMO-targeted drugs[1].

分子量

841.92

Formula

C49H70BF2N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BODIPY-Cyclopamine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BODIPY-Cyclopamine334658-24-1SmoSmoothenedInhibitorinhibitorinhibit

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产品名称：
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目录号：
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