2. Anti-infection
  3. Bacterial
  4. Elsamitrucin

Elsamitrucin  (Synonyms: BMY-28090; SPI-28090; Antibiotic BBM 2478A)

目录号: HY-16192
产品使用指南

摩尔计算器

Elsamitrucin 是一种抗癌剂，能够从放线菌的发酵物中分离得到。Elsamitrucin 在体外对一系列鼠类和人类肿瘤细胞系表现出强大的细胞毒性，暴露 72 小时后的 IC50 值范围为 0.02-3.25 μg/mL。体内研究表明，腹膜内给药时，Elsamitrucin 在各种实验性小鼠肿瘤模型（包括 P388 白血病、L1210 白血病、B16 黑色素瘤和 M5076 肉瘤）中具有显著的抗肿瘤活性。Elsamitrucin 还显示出对人类 MX-1 乳腺肿瘤和 HCT116 结肠肿瘤异种移植的疗效，突出了其广谱细胞毒性和作为不同肿瘤类型和模型的抗肿瘤剂的潜力。

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Elsamitrucin Chemical Structure

Elsamitrucin Chemical Structure

CAS No. : 97068-30-9

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Elsamitrucin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elsamitrucin, derived from actinomycete fermentation, exhibits potent cytotoxicity against a range of murine and human tumor cell lines in vitro, with IC50 values ranging from <0.02 to 3.25 μg/ml after 72-hour exposures. In vivo studies demonstrated significant antitumor activity in various experimental murine tumor models, including P388 leukemia, L1210 leukemia, B16 melanoma, and M5076 sarcoma, when administered intraperitoneally as a water-insoluble free base or as water-soluble lactate or succinate salts. Elsamitrucin also showed efficacy against human MX-1 mammary tumor and HCT116 colon tumor xenografts, highlighting its broad-spectrum cytotoxicity and potential as an antitumor agent across different tumor types and models[1].

分子量

653.63

Formula

C33H35NO13
CAS 号
中文名称

依沙芦星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Elsamitrucin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elsamitrucin97068-30-9BMY-28090 SPI-28090 Antibiotic BBM 2478A依沙芦星BMY28090BMY 28090SPI28090SPI 28090SPI-28090BacterialInhibitorinhibitorinhibit

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