SLC29A1 - solute carrier family 29 member 1 (Augustine blood group) Gene

中文名称：溶质载体家族 29 成员 1 (奥古斯丁血型)

种属: Homo sapiens

同用名: ENT1

基因 ID: 2030 | 基因类型: protein coding

关于 SLC29A1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,219,615-44,234,142 (from NCBI)

This gene has 24 transcripts (splice variants), 290 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 38.0), fat (RPKM 34.4) and 25 other tissues.

功能概要

该基因是平衡核苷转运蛋白家族的成员。该基因编码一种跨膜糖蛋白，定位于质膜和线粒体膜，并介导细胞从周围介质中摄取核苷。该蛋白质被归类为对硝基苄基硫肌苷 (NBMPR) 的抑制敏感的平衡 (相对于浓缩) 转运蛋白。核苷转运体是缺乏从头核苷合成途径的细胞中核苷酸合成所必需的，也是摄取用于癌症和病毒化学疗法的细胞毒性核苷所必需的。已发现该基因的多个选择性剪接变体，编码相同的蛋白质。[RefSeq 提供，2008 年 7 月]

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for Cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

SLC29A1 基因产物(6)

mRNA	Protein	Name
NM_001078175.3	NP_001071643.1	equilibrative nucleoside transporter 1 isoform 1
NM_001078177.2	NP_001071645.1	equilibrative nucleoside transporter 1 isoform 1
NM_001304462.2	NP_001291391.1	equilibrative nucleoside transporter 1 isoform 5
NM_001304465.2	NP_001291394.1	equilibrative nucleoside transporter 1 isoform 3
NM_001304466.2	NP_001291395.1	equilibrative nucleoside transporter 1 isoform 4
NM_001372327.1	NP_001359256.1	equilibrative nucleoside transporter 1 isoform 1

SLC29A1 蛋白结构

Nucleoside_tran

0
100
200
300
400
456 a.a.

蛋白主名

其他名称

equilibrative nucleoside transporter 1

equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter

关联疾病

疾病名称

别名

Fetal Erythroblastosis

Erythroblastosis, Fetal	Ef - Erythroblastosis Foetalis
Erythroblastosis Fetalis	Haemolytic Disease Due To Rhesus Isoimmunisation
Rhesus Isoimmunisation Of The Newborn

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal	Ankylosing Vertebral Hyperostosis
Dish	Disseminated Idiopathic Skeletal Hyperostosis
Forestier Disease	Forestier'S Disease
Hyperostosis Diffuse Idiopathic Skeletal

Vulvar Leiomyosarcoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Lung Pleomorphic Carcinoma

Splenic Tuberculosis

Tuberculosis, Splenic

Vulvar Leiomyoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13153	SLC29A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SLC29A1	VGNC	VGNC:54237
Rattus norvegicus	SLC29A1	RGD	RGD:61899
Mus musculus	SLC29A1	MGD	MGI:1927073
Others	SLC29A1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC29A1 - solute carrier family 29 member 1 (Augustine blood group) Gene

关于 SLC29A1

功能概要

SLC29A1 基因产物(6)

SLC29A1 蛋白结构

关联疾病

直系同源

热门区域

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SLC29A1 - solute carrier family 29 member 1 (Augustine blood group) Gene

关于 SLC29A1

功能概要

SLC29A1 基因产物(6)

SLC29A1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z