Mapk3 - mitogen activated protein kinase 3 Gene

中文名称：有丝分裂原活化蛋白激酶 3

种属: Rattus norvegicus

同用名: p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk

关于 Mapk3

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； MAP 激酶活性；和支架蛋白结合活性。参与多个过程，包括花生四烯酸代谢过程；蜕化；和肽基丝氨酸磷酸化。位于caveola;胞质溶胶；和核质。部分含蛋白质复合物。用于研究胃溃疡；大脑中动脉梗塞; 2型糖尿病；和输尿管梗阻。该基因的人类直系同源物与结肠腺癌有关；结直肠腺癌；子宫内膜腺癌；胰腺导管癌；和肺动脉高压。与人 MAPK3（丝裂原活化蛋白激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonic acid metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytosol; and nucleoplasm. Part of protein-containing complex. Used to study gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]