SLC25A27 - solute carrier family 25 member 27 Gene

中文名称：溶质载体家族 25 成员 27

种属: Homo sapiens

同用名: UCP4

基因 ID: 9481 | 基因类型: protein coding

关于 SLC25A27

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,652,975-46,678,190 (from NCBI)

This gene has 8 transcripts (splice variants), 148 orthologues and 49 paralogues. Broad expression in brain (RPKM 13.5), ovary (RPKM 8.8) and 22 other tissues.

功能概要

线粒体解偶联蛋白 (UCP) 是更大的线粒体阴离子载体蛋白 (MACP) 家族的成员。 UCP 将氧化磷酸化与 ATP 合成分开，能量以热量形式消散，也称为线粒体质子泄漏。 UCP 促进阴离子从线粒体内膜转移到外膜，以及质子从线粒体外膜返回转移到线粒体内膜。它们还降低哺乳动物细胞中的线粒体膜电位。不同的 UCP 会出现组织特异性，并且 UCP 如何转移 H+/OH- 的确切方法尚不清楚。 UCP 包含 MACP 的三个同源蛋白结构域。该基因的转录本仅在脑组织中检测到，并受各种环境条件的特异性调节。可变剪接导致多个转录变体。[RefSeq 提供，2011 年 2 月]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate Oxidative Phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

SLC25A27 基因产物(3)

mRNA	Protein	Name
NM_001204051.2	NP_001190980.1	mitochondrial uncoupling protein 4 isoform 2
NM_001204052.2	NP_001190981.1	mitochondrial uncoupling protein 4 isoform 3
NM_004277.5	NP_004268.3	mitochondrial uncoupling protein 4 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chloride transmembrane transporter activity	IDA IDA: 通过直接分析推断	22524567	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	26182433	GOA
enables proton transmembrane transporter activity	IDA IDA: 通过直接分析推断	22524567	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	10025957	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	10025957	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A27 蛋白结构

Mito_carr

0
100
200
300
323 a.a.

蛋白主名

其他名称

mitochondrial uncoupling protein 4

UCP 4

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Ecthyma

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13108	SLC25A27 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC25A27	MGD	MGI:1921261
Bos taurus	SLC25A27	VGNC	VGNC:34753
Felis catus	SLC25A27	VGNC	VGNC:65267
Macaca mulatta	SLC25A27	VGNC	VGNC:77543
Rattus norvegicus	SLC25A27	RGD	RGD:620787
Canis familiaris	SLC25A27	VGNC	VGNC:46303

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC25A27 - solute carrier family 25 member 27 Gene

关于 SLC25A27

功能概要

SLC25A27 基因产物(3)

SLC25A27 蛋白结构

关联疾病

直系同源

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SLC25A27 - solute carrier family 25 member 27 Gene

关于 SLC25A27

功能概要

SLC25A27 基因产物(3)

SLC25A27 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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