2. Gene
  3. SLC25A27 - solute carrier family 25 member 27 Gene

SLC25A27 - solute carrier family 25 member 27 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 25 成员 27

种属: Homo sapiens

同用名: UCP4

基因 ID: 9481 | 基因类型: protein coding

关于 SLC25A27

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,652,975-46,678,190 (from NCBI)

This gene has 8 transcripts (splice variants), 148 orthologues and 49 paralogues. Broad expression in brain (RPKM 13.5), ovary (RPKM 8.8) and 22 other tissues.

功能概要

线粒体解偶联蛋白 (UCP) 是更大的线粒体阴离子载体蛋白 (MACP) 家族的成员。 UCP 将氧化磷酸化与 ATP 合成分开，能量以热量形式消散，也称为线粒体质子泄漏。 UCP 促进阴离子从线粒体内膜转移到外膜，以及质子从线粒体外膜返回转移到线粒体内膜。它们还降低哺乳动物细胞中的线粒体膜电位。不同的 UCP 会出现组织特异性，并且 UCP 如何转移 H+/OH- 的确切方法尚不清楚。 UCP 包含 MACP 的三个同源蛋白结构域。该基因的转录本仅在脑组织中检测到，并受各种环境条件的特异性调节。可变剪接导致多个转录变体。[RefSeq 提供，2011 年 2 月]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate Oxidative Phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

SLC25A27 基因产物(3)

mRNA Protein Name
NM_001204051.2 NP_001190980.1 mitochondrial uncoupling protein 4 isoform 2
NM_001204052.2 NP_001190981.1 mitochondrial uncoupling protein 4 isoform 3
NM_004277.5 NP_004268.3 mitochondrial uncoupling protein 4 isoform 1

SLC25A27 蛋白结构

Mito_carr

Mito_carr: Mitochondrial carrier protein (21 - 118)

Mito_carr

Mito_carr: Mitochondrial carrier protein (125 - 219)

Mito_carr

Mito_carr: Mitochondrial carrier protein (227 - 317)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

mitochondrial uncoupling protein 4

UCP 4

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome

Mental Retardation With Language Impairment And With Or Without Autistic Features

Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects

Intellectual Disability With Language Impairment And With Or Without Autistic Features
Ecthyma
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13108 SLC25A27 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC25A27 MGD MGI:1921261
Bos taurus SLC25A27 VGNC VGNC:34753
Felis catus SLC25A27 VGNC VGNC:65267
Macaca mulatta SLC25A27 VGNC VGNC:77543
Rattus norvegicus SLC25A27 RGD RGD:620787
Canis familiaris SLC25A27 VGNC VGNC:46303
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