2. 多肽产品
  3. 多肽及其衍生物
  4. 抑制剂与底物肽
  5. Lucicebtide acetate

Lucicebtide acetate 是 CCAAT/增强子结合蛋白 β (C/EBPβ) 的选择性拮抗剂。Lucicebtide acetate 与 C/EBPβ 的亮氨酸拉链结构域结合，防止其二聚化，并泛素依赖性地降解 C/EBPβ。Lucicebtide acetate 可以在 G0/G1 期阻滞细胞周期。Lucicebtide acetate 在癌细胞中表现出细胞毒性。Lucicebtide acetate 在小鼠模型中表现出良好的药代动力学特征，并且抑制肿瘤生长。

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Custom Peptide Synthesis

Lucicebtide acetate Chemical Structure

Lucicebtide acetate Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2600
In-stock
5 mg ￥5200
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Lucicebtide acetate:

Lucicebtide acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lucicebtide acetate is the acetate salt form of Lucicebtide (HY-P10376). Lucicebtide acetate is a selective antagonist for CCAAT/enhancer binding protein β (C/EBPβ). Lucicebtide acetate binds to the leucine zipper domain of C/EBPβ, prevents its dimerization, and ubiquitin-dependently degrades C/EBPβ. Lucicebtide acetate arrests cell cycle at G0/G1 phase. Lucicebtide acetate exhibits cytotoxicity in cancer cells. Lucicebtide acetate exhibits good pharmacokinetic characters and inhibits tumor growth in mouse model[1].

分子量

4724.46 (free base)

Formula

C208H345N69O55S.xC2H4O2
性状

固体

颜色

White to off-white

Sequence

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}
Sequence Shortening

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Lucicebtide acetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LucicebtideOthersU251A549A375DU145MCF7lung cancerglioblastomaPBMCBMMCC57BL/6J mouseInhibitorinhibitorinhibit

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产品名称：
Lucicebtide acetate
目录号：
HY-P10376B
需求量：

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