2. Academic Validation
  3. Two limonoids from Turraea obtusifolia (Meliaceae), prieurianin and rohitukin, antagonise 20-hydroxyecdysone action in a Drosophila cell line

Two limonoids from Turraea obtusifolia (Meliaceae), prieurianin and rohitukin, antagonise 20-hydroxyecdysone action in a Drosophila cell line

  • Arch Insect Biochem Physiol. 1997;35(1-2):211-7. doi: 10.1002/(SICI)1520-6327(1997)35:1/2<211::AID-ARCH19>3.0.CO;2-E.
S D Sarker 1,  T Savchenko,  P Whiting,  V Sik,  L Dinan
Affiliations

Affiliation

  • 1 Department of Biological Sciences, University of Exeter, Washington Singer Laboratories, Devon, UK.
PMID: 9131785 DOI: 10.1002/(SICI)1520-6327(1997)35:1/2<211::AID-ARCH19>3.0.CO;2-E
Abstract

Bioassay-assisted HPLC analyses yielded two prieurianin-type limonoids, prieurianin and rohitukin, from the seeds of Turraea obtusifolia, which act as antagonists of 20-hydroxyecdysone action in the Drosophila melanogaster BII cell line. With a 20-hydroxyecdysone concentration of 5 x 10(-8) M, the ED50 values for prieurianin and rohitukin are 10(-5) M and 1.25 x 10(-4) M, respectively.

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  • HY-126589
    蜕皮激素拮抗剂
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