2. Neuronal Signaling
  3. α-synuclein
  4. α-Synuclein inhibitor 8

α-Synuclein inhibitor 8 是一种有效的 α-Synuclein 抑制剂，IC50 值为 2.5 µM。α-Synuclein inhibitor 8 对 α-Synuclein 纤维的聚集和解聚具有高度抑制作用。α-Synuclein inhibitor 8 减少了神经元细胞中内含物的形成，能修复受损的神经元并改善帕金森病 (PD) 样症状。α-Synuclein inhibitor 8 具有高抗氧化性和低细胞毒性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

α-Synuclein inhibitor 8 Chemical Structure

α-Synuclein inhibitor 8 Chemical Structure

CAS No. : 2883627-64-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

α-Synuclein inhibitor 8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity[1].

IC50 & Target

IC50: 2.5 µM[1]
体外研究
(In Vitro)

α-Synuclein inhibitor 8 (Compound 2ee) (0-100 μM；0-96 h) 以剂量依赖的方式抑制 α-Synuclein 的聚集[1]。
α-Synuclein inhibitor 8 (100 µM；48 h) 将成熟的纤维分解成可溶性蛋白质及少量的短的不溶性纤维[1]。
α-Synuclein inhibitor 8 (1-1000 µM；0.5 h 或 24 h) 以剂量依赖的方式增加活性氧的清除率。α-Synuclein inhibitor 8 对 H4 和 SH-SY5Y 细胞毒性低 (细胞活力高于 80 %)[1]。
α-Synuclein inhibitor 8 (10 µM；38 h) 对 H4 细胞内 α-Synuclein 聚集和包涵体形成有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Synuclein inhibitor 8 相关抗体:

Cell Viability Assay[1]

Cell Line: H4 and SH-SY5Y cells.
Concentration: 1, 3, 10, 30, 100, 300, 500 and 1000 µM.
Incubation Time: 24 h.
Result: Showed low cytotoxicity.
体内研究
(In Vivo)

α-Synuclein inhibitor 8 (Compound 2ee) (0.9 μg/μL；静脉注射；单剂量) 显著改善帕金森病 C57 小鼠模型的抓力减弱、四肢僵硬和平衡不良等帕金森 (PD) 样症状。α-Synuclein inhibitor 8 对帕金森病 C57 小鼠模型的大脑中尾壳核 (CPu) 和黑质网状部 (SNr) 具有神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-OHDA-lesioned C57 mice model of PD (8-12 weeks, 20-28 g)[1].
Dosage: 0.9 μg/μL.
Administration: Intravenous injection (right striatum); single dose.
Result: Exhibited neuroprotective and repair effects.
分子量

432.43

Formula

C24H20N2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Synuclein inhibitor 8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Synuclein inhibitor 82883627-64-1α-synucleinα-SynH4 cellsSH-SY5Y cellsMiceParkinson’s disease PDInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
α-Synuclein inhibitor 8
目录号：
HY-152552
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z