2. NF-κB
  3. NF-κB
  4. 3'-Sialyllactose

3'-Sialyllactose  (Synonyms: 3'-SL)

目录号: HY-108065
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摩尔计算器

3'-Sialyllactose (3'-SL) 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3'-Sialyllactose 是毒性等级最低的普通碳水化合物，可用于炎症的研究。

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3'-Sialyllactose Chemical Structure

3'-Sialyllactose Chemical Structure

CAS No. : 35890-38-1

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规格 价格 是否有货
1 mg ￥4500
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3'-Sialyllactose 的其他形式现货产品:

Other Forms of 3'-Sialyllactose:

3'-Sialyllactose 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3].

体外研究
(In Vitro)

3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3'-Sialyllactose (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].
3'-Sialyllactose (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3'-Sialyllactose 相关抗体:

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 0, 50, 100 and 250 μM
Incubation Time: 24-36 hours
Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
体内研究
(In Vivo)

3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3'-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3'-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1]
Dosage: 10, 50 and 100 mg/kg
Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
分子量

633.55

Formula

C23H39NO19
CAS 号
结构分类
初始来源

Human milk
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3'-Sialyllactose 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Sialyllactose35890-38-13'-SLNF-κBNuclear factor-κBNuclear factor-kappaBpolysaccharideprebiotichomeostasisinflammationimmuneCol2a1osteoarthritismiceInhibitorinhibitorinhibit

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