MicroRNA

miRNA

MicroRNAs (miRNAs) are a naturally occurring class of small (approximately 22 nucleotides long) non-coding RNAs that regulate post-transcriptional gene expression to control cellular processes, development, cell differentiation, and homeostasis. MicroRNAs are essential for embryo, cell, and tissue development, regulating cell differentiation, proliferation, and apoptosis, hence their importance in human reproduction. Meanwhile, abnormal expression or function of miRNAs are found to be closely associated with the occurrence or development of various human diseases, including cancers. In light of their significant roles in physiology and pathology, miRNAs are emerging as novel biomolecular targets for chemical-biological studies, including regulation and detection.

Multiple steps are involved in the generation of miRNAs. Most miRNAs are produced by the canonical biogenesis pathway, which involves transcription by RNA polymerase II to make a primary transcript (pri-miRNA) and cleavage by the microprocessor complex to yield a hairpin precursor miRNA (pre-miRNA) in the nucleus. The pre-miRNA is then exported into the cytoplasm, where cleavage by the enzyme Dicer creates a double-stranded RNA duplex. Only a single strand from the double-stranded RNA duplex forms the mature miRNA and is incorporated into the RNA-induced silencing complex (RISC), which guides the binding of Argonaute (AGO) proteins in the RISC to the 3’untranslated region (UTR) to either repress protein translation or promote mRNA degradation. In addition to canonical miRNA biogenesis pathways, non-canonical microprocessor-independent or Dicer-independent miRNA biogenesis pathways also exist. Despite miRNAs being mostly involved in the down-regulation of gene expression, there are reports of miRNAs promoting gene expression. In addition, relationships between miRNAs and their targets are not always one-to-one in a specific cell type. In fact, a single miRNA may regulate many mRNA targets, and conversely, a single mRNA target also can be regulated by many miRNAs.

MicroRNA 相关产品 (18472)
抗体 (1)

By Effects:	抑制剂 (24) 激动剂 (1) 拮抗剂 (2) 激活剂 (11) 调节剂 (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-R00499

hsa-miR-27a-5p mimic hsa-miR-27a-5p 模拟物
hsa-miR-27a-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-27a-5p mimic hsa-miR-27a-5p mimic

HY-R00268

hsa-miR-138-5p mimic hsa-miR-138-5p 模拟物
hsa-miR-138-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-138-5p mimic hsa-miR-138-5p mimic

HY-R00674

hsa-miR-320c mimic hsa-miR-320c 模拟物
hsa-miR-320c mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-320c mimic hsa-miR-320c mimic

HY-RI00421

hsa-miR-205-5p inhibitor
hsa-miR-205-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-205-5p inhibitor hsa-miR-205-5p inhibitor

HY-R01973A

hsa-miR-655-3p agomir
hsa-miR-655-3p agomir 是一种经过特殊化学修饰的miRNA模拟物，miRNA成熟链全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA agomir 可以模拟内源性miRNA，上调miRNA活性。与普通模拟物相比，miRNA agomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

hsa-miR-655-3p agomir hsa-miR-655-3p agomir

HY-RI02495

hsa-miR-887-3p inhibitor
hsa-miR-887-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-887-3p inhibitor hsa-miR-887-3p inhibitor

HY-R02536

hsa-miR-9-5p mimic hsa-miR-9-5p 模拟物
hsa-miR-9-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-9-5p mimic hsa-miR-9-5p mimic

HY-RI00406A

hsa-miR-200b-3p antagomir		99.41%
hsa-miR-200b-3p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链，全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能。相比于miRNA inhibitor，miRNA antagomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

hsa-miR-200b-3p antagomir hsa-miR-200b-3p antagomir

HY-RI00500

hsa-miR-27b-3p inhibitor
hsa-miR-27b-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-27b-3p inhibitor hsa-miR-27b-3p inhibitor

HY-R00250

hsa-miR-132-5p mimic hsa-miR-132-5p 模拟物
hsa-miR-132-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-132-5p mimic hsa-miR-132-5p mimic

HY-RI00499

hsa-miR-27a-5p inhibitor
hsa-miR-27a-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-27a-5p inhibitor hsa-miR-27a-5p inhibitor

HY-RI00714

hsa-miR-34a-5p inhibitor
hsa-miR-34a-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-34a-5p inhibitor hsa-miR-34a-5p inhibitor

HY-132601

Cobomarsen	Inhibitor
Cobomarsen (MRG-106) 是 miR-155 的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK 和 PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

HY-R00287

hsa-miR-146a-5p mimic hsa-miR-146a-5p 模拟物
hsa-miR-146a-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-146a-5p mimic hsa-miR-146a-5p mimic

HY-R00329

hsa-miR-181a-5p mimic hsa-miR-181a-5p 模拟物
hsa-miR-181a-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-181a-5p mimic hsa-miR-181a-5p mimic

HY-RI00428

hsa-miR-20b-5p inhibitor
hsa-miR-20b-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-20b-5p inhibitor hsa-miR-20b-5p inhibitor

HY-R02327

hsa-miR-6883-5p mimic hsa-miR-6883-5p 模拟物
hsa-miR-6883-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-6883-5p mimic hsa-miR-6883-5p mimic

HY-RI00686

hsa-miR-328-3p inhibitor
hsa-miR-328-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-328-3p inhibitor hsa-miR-328-3p inhibitor

HY-RI00147

hsa-miR-1248 inhibitor
hsa-miR-1248 inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-1248 inhibitor hsa-miR-1248 inhibitor

HY-RI00248

hsa-miR-132-3p inhibitor
hsa-miR-132-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-132-3p inhibitor hsa-miR-132-3p inhibitor

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