1. Anti-infection
  2. SARS-CoV
  3. Adintrevimab

Adintrevimab  (Synonyms: 艾定韦单抗; ADG 20)

目录号: HY-P99423 纯度: 96.94%
COA

Adintrevimab (ADG 20) 是一种人 IgG1 单克隆 SARS-CoV (SARS-CoV) 抗体。Adintrevimab 抑制 SARS-CoV-2 变体和其他具有大流行潜力的 SARS 样冠状病毒。

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CAS No. : 2516243-54-0

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规格 价格 是否有货 数量
1 mg ¥3000
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5 mg ¥7800
In-stock
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].

同型

Human IgG1 lambda1

推荐同型对照抗体
体外研究
(In Vitro)

Adintrevimab 的 Fc 片段区域经过修饰以延长其半衰期。 Adintrevimab 与 SARS-CoV-2 刺突糖蛋白受体结合域中的一个独特表位结合,该表位与血管紧张素转换酶 2 结合位点部分重叠,在 sarbecoviruses 中高度保守。在体外,Adintrevimab 已证明对 SARS-CoV-2(包括 Alpha、Beta、Gamma 和 Delta)的大多数变体和亚系以及其他 SARS 样病毒具有有效的中和活性。Adintrevimab 对 Omicron BA.1/BA.1.1 的体外活性降低,对 BA.2、BA.3、BA.4 和 BA.5 缺乏活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Adintrevimab(9.25、55、333 或 2,000μg;腹腔注射;一次)以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]
Adintrevimab(5-25mg/kg;静脉注射;一次)以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg)
Administration: Intraperitoneal injection; single dose
Result: Showed significant reduction in lung viral load and virus-induced lung pathology.
Animal Model: Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 5 mg/kg, 25 mg/kg
Administration: Intravenous injection; single dose
Result: Reduced pulmonary inflammation.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾定韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 lambda2
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Adintrevimab
目录号:
HY-P99423
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