2. Autophagy Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Autophagy Ferroptosis Reactive Oxygen Species
  4. anti-TNBC agent-6

anti-TNBC agent-6 (compound pt-3) 是一种有效的抗三阴性乳腺癌 (TNBC) 剂。anti-TNBC agent-6 显示细胞毒活性。anti-TNBC agent-6 诱导自噬 ( autophagy) 和铁死亡 (ferroptosis)。anti-TNBC agent-6 增强细胞内 ROS 积累。anti-TNBC agent-6 具有抗肿瘤活性，具有乳腺癌研究的潜力。

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anti-TNBC agent-6 Chemical Structure

anti-TNBC agent-6 Chemical Structure

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anti-TNBC agent-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer[1].

体外研究
(In Vitro)

anti-TNBC agent-6 (compound pt-3) (48 h) 对 MDA-MB-231、MCF-7、B16-F10、SK-OV-3、WI-38 细胞具有细胞毒性[1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) 在 MDA-MB-231 细胞中以时间依赖性方式增加 Beclin-1、LC3-II 的表达来诱导自噬 [1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) 以时间依赖性方式降低 GPX4 的表达来诱导铁死亡[1]。
anti-TNBC agent-6 (1, 2 µM) 以剂量依赖性方式增加 MDA-MB-231 细胞中的 MDA 含量[1]。
anti-TNBC agent-6 (2 µM) 可增强细胞内 ROS 积累并增加细胞内的不稳定铁池 (LIP)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

anti-TNBC agent-6 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, A549/CDDP cells
Concentration: 0-28 µM
Incubation Time: 48 h
Result: Showed cytotoxic activity with IC50s of 2.84, 4.12 µM for A549, A549/CDDP cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2 µM
Incubation Time: 0, 12, 24, 36, 48 h
Result: Increased the expression of Beclin-1, LC3-II in a time dependent manner.
体内研究
(In Vivo)

anti-TNBC agent-6 (10 mg/kg; i.p.; on days 0, 3, 6, 9, 12, 15, and 18) 在 MDA-MB-231 异种移植模型中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25 g, 5 weeks, female KM mice (MDA-MB-231 xenograft model)[1]
Dosage: 10 mg/kg
Administration: I.p.; on days 0, 3, 6, 9, 12, 15, and 18
Result: Significantly inhibited tumor growth compared to the vehicle controls, elicited an inhibition rates of tumor growth (IRT) as high as 65.3%.
分子量

768.51

Formula

C28H18F6N3O2PPt-
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

anti-TNBC agent-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

anti-TNBC agent-6AutophagyFerroptosisReactive Oxygen SpeciesautophagyferroptosisROSbreast cancerMDA-MB-231 cellsMDA contentBeclin-1LC3-IIInhibitorinhibitorinhibit

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