2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 83

Anticancer agent 83 是一种强效抗癌剂，抑制 LOX IMVI 细胞生长的 GI50 为 0.15 mM。Anticancer agent 83 能够降低线粒体膜电位，并诱导 DNA 损伤，以诱导白血病细胞凋亡 (apoptosis)。

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Anticancer agent 83 Chemical Structure

Anticancer agent 83 Chemical Structure

CAS No. : 904815-29-8

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Anticancer agent 83 相关抗体

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生物活性

Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI50 value of 0.15 mM. Anticancer agent 83 reduces mitochondrial membrane potential and induces DNA damage to induces leukemia cells apoptosis[1].

体外研究
(In Vitro)

Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human colon carcinoma HCT116 p53−/− cells with deletion of P53 gene (GI50=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI50=7.4 μM), human ovarian carcinoma Skov 3 cells (GI50=10 μM), and human chronic myelogenous leukemia K562 cells (GI50=5.4 μM)[1].
Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases mitochondrial membrane potential[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 83 相关抗体:

Cell Viability Assay[1]

Cell Line: Human colon carcinoma HCT116 p53−/− cells with deletion of P53 gene, human epidermoid cervix carcinoma KB3-1, human ovarian carcinoma Skov 3 cells, and human chronic myelogenous leukemia K562 cells
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 24 hours
Result: Inhibited cell viability in different cells with GI50s of 8.4 M (HCT116 p53−/−), 7.4 M (KB3-1), 10 M (Skov 3), and 5.4 M (K562), respectively.

Immunofluorescence[1]

Cell Line: Jurkat cells
Concentration: 0.5 μM
Incubation Time: 24 hours
Result: Induced morphological changes (including apoptotic bodies, membrane blebbing, chromatin condensation), and DNA fragmentation in Jurkat T-cells.
分子量

377.46

Formula

C20H19N5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 83 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Anticancer agent 83904815-29-8Anticancer agent83Anticancer agent-83Apoptosismitochondrial membrane potentialDNA damageleukemia cellJurkat T-cellsInhibitorinhibitorinhibit

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