2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-11

Antiproliferative agent-11 (compound 7) 是一种具有抗增殖活性和选择性的 Ruthenium(II)-Tris-pyrazolylmethane 复合物。Antiproliferative agent-11 对 MCF-7，HeLa，518A2，HCT116 和 RD 细胞具有抗增殖活性，其 IC50 值分别为 6，10，6.8，6.7 和 6 μM。Antiproliferative agent-11 可用于癌症的研究。

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Antiproliferative agent-11 Chemical Structure

Antiproliferative agent-11 Chemical Structure

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Antiproliferative agent-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer[1].

IC50 & Target

IC50: 6 μM (MCF-7), 6 μM (RD), 6.7 μM (HCT116), 6.8 μM (518A2) , 10 μM (HeLa)[1]
体外研究
(In Vitro)

Antiproliferative agent-11 (0-100 μM; 72 h) exhibits antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD[1].
Antiproliferative agent-11 (26.8 μM; 24 h) induces apoptosis in HCT116 cells[1].
Antiproliferative agent-11 (10-26.8 μM; 72 h) promotes HCT116 cells death by a mitochondria-dependent mechanism[1].
Antiproliferative agent-11 (0-50 μM; 24 h) inhibits HCT116 cells under 3D cell culture conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-11 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, HeLa, 518A2, HCT116, RD and MRC5pd30
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Showed selectively antiproliferative activity to MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 26.8 μM
Incubation Time: 24 hours
Result: Induced apoptosis in HCT116 to achieve antiproliferative activity.

Cell Viability Assay[1]

Cell Line: HCT116
Concentration: 10, 12.4 and 26.8 μM
Incubation Time: 72 hours
Result: Reduced mitochondrial membrane potential and generated mitochondrial depolarization.

Cell Proliferation Assay[1]

Cell Line: HCT116
Concentration: 0-50 μM
Incubation Time: 5 hours
Result: Inhibited HCT116 with an IC50 value of 12.2 μM under 3D cell culture conditions.
分子量

772.56

Formula

C31H34Cl2N6O3P2Ru
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-11Antiproliferative agent11Antiproliferative agent 11Apoptosisantiproliferativecalcium homeostasiscancer3D cell cultureInhibitorinhibitorinhibit

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