2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 17

Apoptosis inducer 17 是一种 Curcumin-Piperlongumine 杂合分子，可通过激活肺癌细胞中的 JNK 信号通路来增加细胞周期停滞和细胞凋亡 (apoptosis)。

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Apoptosis inducer 17 Chemical Structure

Apoptosis inducer 17 Chemical Structure

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Apoptosis inducer 17 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells[1].

体外研究
(In Vitro)

Apoptosis inducer 17（化合物 CP；0.027-60 μM；72 h）抑制细胞增殖，对 H446、H1299 和 SBC-2 细胞的 IC50 值分别为 0.021 μM、0.027 μM 和 0.73 μM[ 1]。
Apoptosis inducer 17（化合物 CP；0.03-0.3 μM；24 小时）对集落形成具有优异的抑制作用。JNK-IN-17 在 H446 和 H1299 细胞中诱导剂量依赖性 G2/M 期阻滞[1]。
Apoptosis inducer 17（化合物 CP；0.03-0.3 μM；24 小时）通过 caspase 活性介导诱导 H446 和 H1299 细胞凋亡，并且还激活 JNK 信号级联[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 17 相关抗体:

Cell Proliferation Assay[1]

Cell Line: H446, H1299, and SBC-2 cells
Concentration: 60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
Incubation Time: 72 h
Result: Effectively inhibited cell proliferation.

Cell Cycle Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Induced dose-dependent G2/M arrest.

Apoptosis Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Induced apoptosis of H446 and H1299 cells.

Western Blot Analysis[1]

Cell Line: H446, H1299 cells
Concentration: 0.03 μM, 0.1 μM, 0.3 μM
Incubation Time: 24 h
Result: Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.
体内研究
(In Vivo)

Apoptosis inducer 17（化合物 CP；10 mg/kg；腹腔注射；每天两次；持续 15 天）显示 H446 细胞生长显着减少，而体重没有任何显着变化[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (4-6 weeks old) injected with H446 cells[1]
Dosage: 10 mg/kg
Administration: ip; twice a day; for 15 days
Result: Prevented growth of lung cancer in xenograft tumors.
分子量

453.48

Formula

C25H27NO7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 17 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Apoptosis inducer 17Apoptosis inducer17Apoptosis inducer-17ApoptosisApoptosis InducerJNKCurcuminPiperlonguminecell cycle arrestanticancerInhibitorinhibitorinhibit

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